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2fv8
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2fv8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fv8, resolution 1.90Å" /> '''The crystal structu...) |
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| - | [[Image:2fv8.gif|left|200px]]<br /> | ||
| - | <applet load="2fv8" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2fv8, resolution 1.90Å" /> | ||
| - | '''The crystal structure of RhoB in the GDP-bound state'''<br /> | ||
| - | == | + | ==The crystal structure of RhoB in the GDP-bound state== |
| - | + | <StructureSection load='2fv8' size='340' side='right'caption='[[2fv8]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2fv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FV8 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fv8 OCA], [https://pdbe.org/2fv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fv8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fv8 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/RHOB_HUMAN RHOB_HUMAN] Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.<ref>PMID:9478917</ref> <ref>PMID:10508588</ref> <ref>PMID:15226397</ref> <ref>PMID:16236794</ref> <ref>PMID:21373644</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fv8_consurf.spt"</scriptWhenChecked> | |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | + | </jmolCheckbox> | |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fv8 ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | + | ||
| - | [ | + | |
| - | [[ | + | |
| - | [ | + | |
| - | + | ||
| - | + | ||
| - | + | ==See Also== | |
| + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | ||
| + | *[[Rho GTPase 3D structures|Rho GTPase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith C]] | ||
| + | [[Category: Bray J]] | ||
| + | [[Category: Doyle D]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Gorrec F]] | ||
| + | [[Category: Johansson C]] | ||
| + | [[Category: Papagrigoriou E]] | ||
| + | [[Category: Schoch G]] | ||
| + | [[Category: Smee C]] | ||
| + | [[Category: Soundararajan M]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Turnbull AP]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
The crystal structure of RhoB in the GDP-bound state
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bray J | Doyle D | Edwards A | Gorrec F | Johansson C | Papagrigoriou E | Schoch G | Smee C | Soundararajan M | Sundstrom M | Turnbull AP | Weigelt J | Von Delft F
