2cg4

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[[Image:2cg4.gif|left|200px]]
 
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==Structure of E.coli AsnC==
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The line below this paragraph, containing "STRUCTURE_2cg4", creates the "Structure Box" on the page.
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<StructureSection load='2cg4' size='340' side='right'caption='[[2cg4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cg4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CG4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASN:ASPARAGINE'>ASN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2cg4| PDB=2cg4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cg4 OCA], [https://pdbe.org/2cg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cg4 RCSB], [https://www.ebi.ac.uk/pdbsum/2cg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cg4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASNC_ECOLI ASNC_ECOLI] Activator of asnA transcription; autogenous regulator of its own transcription; and repressor of the expression of gidA at a post-transcriptional level.<ref>PMID:3909107</ref> <ref>PMID:2864330</ref> <ref>PMID:2836709</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/2cg4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cg4 ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF E.COLI ASNC'''
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==See Also==
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*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
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== References ==
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==Overview==
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<references/>
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The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both the first bacterial and the highest resolution structures for members of the family. Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding. Bacillus subtilis LrpC is a global regulator involved in chromosome condensation. Our AsnC-asparagine structure is the first for a regulator-effector complex and is revealed as an octameric disc. Key ligand recognition residues are identified together with a route for ligand access. The LrpC structure reveals a stable octamer supportive of a topological role in dynamic DNA packaging. The structures yield significant clues to the functionality of Lrp/AsnC-type regulators with respect to ligand binding and oligomerization states as well as to their role in specific and global DNA regulation.
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__TOC__
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</StructureSection>
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==About this Structure==
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2CG4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CG4 OCA].
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==Reference==
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Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family., Thaw P, Sedelnikova SE, Muranova T, Wiese S, Ayora S, Alonso JC, Brinkman AB, Akerboom J, van der Oost J, Rafferty JB, Nucleic Acids Res. 2006 Mar 9;34(5):1439-49. Print 2006. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16528101 16528101]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Akerboom, J.]]
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[[Category: Akerboom J]]
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[[Category: Alonso, J C.]]
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[[Category: Alonso JC]]
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[[Category: Ayora, S.]]
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[[Category: Ayora S]]
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[[Category: Brinkman, A B.]]
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[[Category: Brinkman AB]]
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[[Category: Muranova, T.]]
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[[Category: Muranova T]]
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[[Category: Oost, J Van Der.]]
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[[Category: Rafferty JB]]
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[[Category: Rafferty, J B.]]
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[[Category: Sedelnikova SE]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Thaw P]]
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[[Category: Thaw, P.]]
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[[Category: Wiese S]]
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[[Category: Wiese, S.]]
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[[Category: Van der Oost J]]
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[[Category: Asnc]]
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[[Category: Dna binding]]
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[[Category: Dna-binding]]
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[[Category: Ffrp]]
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[[Category: Lrp family]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:03:44 2008''
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Current revision

Structure of E.coli AsnC

PDB ID 2cg4

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