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| - | [[Image:2cmz.gif|left|200px]] | + | #REDIRECT [[5i2m]] This PDB entry is obsolete and replaced by 5i2m |
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| - | {{STRUCTURE_2cmz| PDB=2cmz | SCENE= }}
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| - | '''CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION'''
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| - | ==Overview==
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| - | The vesicular stomatitis virus has an atypical membrane fusion glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms at the virus surface. Membrane fusion is triggered during the transition from the high- to low-pH form. The structure of G in its low-pH form shows the classic hairpin conformation observed in all other fusion proteins in their postfusion conformation, in spite of a novel fold combining features of fusion proteins from classes I and II. The structure provides a framework for understanding the reversibility of the G conformational change. Unexpectedly, G is homologous to gB of herpesviruses, which raises important questions on viral evolution.
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| - | ==About this Structure==
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| - | 2CMZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMZ OCA].
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| - | ==Reference==
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| - | Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G., Roche S, Bressanelli S, Rey FA, Gaudin Y, Science. 2006 Jul 14;313(5784):187-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16840692 16840692]
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| - | [[Category: Single protein]]
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| - | [[Category: Vesicular stomatitis indiana virus]]
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| - | [[Category: Bressanelli, S.]]
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| - | [[Category: Roche, S.]]
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| - | [[Category: Envelope protein]]
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| - | [[Category: Glycoprotein]]
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| - | [[Category: Lipoprotein]]
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| - | [[Category: Membrane]]
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| - | [[Category: Membrane protein]]
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| - | [[Category: Transmembrane]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:32:51 2008''
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