2cqd

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[[Image:2cqd.gif|left|200px]]
 
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==Solution Structure of the RNA recognition motif in RNA-binding region containing protein 1==
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The line below this paragraph, containing "STRUCTURE_2cqd", creates the "Structure Box" on the page.
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<StructureSection load='2cqd' size='340' side='right'caption='[[2cqd]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cqd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CQD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cqd OCA], [https://pdbe.org/2cqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cqd RCSB], [https://www.ebi.ac.uk/pdbsum/2cqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cqd ProSAT], [https://www.topsan.org/Proteins/RSGI/2cqd TOPSAN]</span></td></tr>
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{{STRUCTURE_2cqd| PDB=2cqd | SCENE= }}
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</table>
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== Function ==
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'''Solution Structure of the RNA recognition motif in RNA-binding region containing protein 1'''
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[https://www.uniprot.org/uniprot/RBM38_HUMAN RBM38_HUMAN] RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.<ref>PMID:17050675</ref> <ref>PMID:19285943</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2CQD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CQD OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cq/2cqd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cqd ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Someya T]]
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[[Category: Someya, T.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rna recognition motif]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:47:59 2008''
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Current revision

Solution Structure of the RNA recognition motif in RNA-binding region containing protein 1

PDB ID 2cqd

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OCA

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