2gao

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(New page: 200px<br /> <applet load="2gao" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gao, resolution 2.000&Aring;" /> '''Crystal Structure ...)
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[[Image:2gao.gif|left|200px]]<br />
 
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<applet load="2gao" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2gao, resolution 2.000&Aring;" />
 
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'''Crystal Structure of Human SAR1a in Complex With GDP'''<br />
 
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==Disease==
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==Crystal Structure of Human SAR1a in Complex With GDP==
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Known diseases associated with this structure: Anderson disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]], Chylomicron retention disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]], Chylomicron retention disease with Marinesco-Sjogren syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607690 607690]]
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<StructureSection load='2gao' size='340' side='right'caption='[[2gao]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GAO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gao OCA], [https://pdbe.org/2gao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gao RCSB], [https://www.ebi.ac.uk/pdbsum/2gao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gao ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAR1A_HUMAN SAR1A_HUMAN] Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).<ref>PMID:17005010</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/2gao_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gao ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2GAO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with GDP and UNX as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GAO OCA].
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Dimov, S.]]
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[[Category: Dimov S]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Park, H.]]
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[[Category: Park H]]
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[[Category: SGC, Structural.Genomics.Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Tempel W]]
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[[Category: Tempel, W.]]
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[[Category: Wang J]]
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[[Category: Wang, J.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yaniw D]]
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[[Category: Yaniw, D.]]
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[[Category: GDP]]
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[[Category: UNX]]
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[[Category: gdp]]
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[[Category: gtpase]]
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[[Category: sgc]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:16:49 2007''
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Current revision

Crystal Structure of Human SAR1a in Complex With GDP

PDB ID 2gao

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