2cs7

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[[Image:2cs7.gif|left|200px]]
 
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==1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold==
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The line below this paragraph, containing "STRUCTURE_2cs7", creates the "Structure Box" on the page.
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<StructureSection load='2cs7' size='340' side='right'caption='[[2cs7]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cs7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CS7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2cs7| PDB=2cs7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cs7 OCA], [https://pdbe.org/2cs7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cs7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cs7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cs7 ProSAT]</span></td></tr>
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</table>
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'''1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold'''
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0H2UQ89_STRPN A0A0H2UQ89_STRPN]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The recently described pneumococcal histidine triad protein family has been shown to be highly conserved within the pneumococcus. As part of our structural genomics effort on proteins from Streptococcus pneumoniae, we have expressed, crystallised and solved the structure of PhtA-166-220 at 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220 shows no similarity to any protein structure. The overall fold contains 3beta-strands and a single short alpha-helix. The structure appears to contain a novel zinc binding motif. The remaining 4 histidine triad repeats from PhtA have been modelled based on the crystal structure of the PhtA histidine triad repeat 2. From this modelling work, we speculate that only three of the five histidine triad repeats contain the residues in the correct geometry to allow the binding of a zinc ion.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2cs7_consurf.spt"</scriptWhenChecked>
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2CS7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CS7 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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1.2 Angstroms crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold., Riboldi-Tunnicliffe A, Isaacs NW, Mitchell TJ, FEBS Lett. 2005 Oct 10;579(24):5353-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16194532 16194532]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cs7 ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: Isaacs, N W.]]
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[[Category: Isaacs NW]]
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[[Category: Mitchell, T J.]]
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[[Category: Mitchell TJ]]
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[[Category: Riboldi-Tunnicliffe, A.]]
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[[Category: Riboldi-Tunnicliffe A]]
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[[Category: Phta]]
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[[Category: Pneumococcal histidine triad protein]]
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[[Category: S pneumoniae]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:55:55 2008''
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Current revision

1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold

PDB ID 2cs7

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