2cuh

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[[Image:2cuh.gif|left|200px]]
 
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==Solution structure of the 31st fibronectin type III domain of the human tenascin X==
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The line below this paragraph, containing "STRUCTURE_2cuh", creates the "Structure Box" on the page.
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<StructureSection load='2cuh' size='340' side='right'caption='[[2cuh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cuh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cuh OCA], [https://pdbe.org/2cuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cuh RCSB], [https://www.ebi.ac.uk/pdbsum/2cuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cuh ProSAT], [https://www.topsan.org/Proteins/RSGI/2cuh TOPSAN]</span></td></tr>
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{{STRUCTURE_2cuh| PDB=2cuh | SCENE= }}
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</table>
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== Disease ==
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'''Solution structure of the 31st fibronectin type III domain of the human tenascin X'''
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[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN] Defects in TNXB are the cause of tenascin-X deficiency (TNXD) [MIM:[https://omim.org/entry/606408 606408]. TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers-Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients.
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== Function ==
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[https://www.uniprot.org/uniprot/TENX_HUMAN TENX_HUMAN] Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors.<ref>PMID:17033827</ref>
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==Disease==
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== Evolutionary Conservation ==
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Known disease associated with this structure: Ehlers-Danlos due to tenascin X deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600985 600985]], Ehlers-Danlos syndrome, hypermobility type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600985 600985]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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2CUH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUH OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cu/2cuh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cuh ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: Ohnishi, S.]]
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[[Category: Ohnishi S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Extracellular matrix]]
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[[Category: Fibronectin type iii domain]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Tenascin x precursor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:05:36 2008''
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Current revision

Solution structure of the 31st fibronectin type III domain of the human tenascin X

PDB ID 2cuh

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OCA

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