2cw3

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[[Image:2cw3.gif|left|200px]]
 
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==X-ray structure of PmSOD2, superoxide dismutase from Perkinsus marinus==
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The line below this paragraph, containing "STRUCTURE_2cw3", creates the "Structure Box" on the page.
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<StructureSection load='2cw3' size='340' side='right'caption='[[2cw3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2cw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Perkinsus_marinus Perkinsus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CW3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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{{STRUCTURE_2cw3| PDB=2cw3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw3 OCA], [https://pdbe.org/2cw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2cw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cw3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8ISI9_9ALVE Q8ISI9_9ALVE] Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity).[RuleBase:RU000414]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/2cw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cw3 ConSurf].
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<div style="clear:both"></div>
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'''X-ray structure of PmSOD2, superoxide dismutase from Perkinsus marinus'''
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==See Also==
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*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Perkinsus marinus, a facultative intracellular parasite of the eastern oyster Crassostrea virginica, is responsible for mass mortalities of oyster populations. P. marinus trophozoites survive and proliferate within oyster hemocytes, invading most tissues and fluids, thus causing a systemic infection that eventually kills the host. The phagocytosis of P. marinus trophozoites lacks a respiratory burst, suggesting that the parasite has mechanisms that actively abrogate the host's oxidative defense responses. One mechanism and the first line of defense against oxidative damage is the dismutation of superoxide radical to molecular oxygen and hydrogen peroxide by superoxide dismutases (SODs). P. marinus possesses two iron-cofactored SODs, PmSOD1 and PmSOD2. Here, the crystallization and X-ray structures of both PmSOD1 and PmSOD2 are presented.
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[[Category: Large Structures]]
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==About this Structure==
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2CW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Perkinsus_marinus Perkinsus marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW3 OCA].
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==Reference==
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Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus., Asojo OA, Schott EJ, Vasta GR, Silva AM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1072-5. Epub 2006 Oct 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17077482 17077482]
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[[Category: Perkinsus marinus]]
[[Category: Perkinsus marinus]]
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[[Category: Single protein]]
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[[Category: Asojo OA]]
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[[Category: Superoxide dismutase]]
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[[Category: Schott EJ]]
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[[Category: Asojo, O A.]]
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[[Category: Silva AM]]
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[[Category: Schott, E J.]]
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[[Category: Vasta GR]]
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[[Category: Silva, A M.]]
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[[Category: Vasta, G R.]]
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[[Category: Sod]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:11:17 2008''
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Current revision

X-ray structure of PmSOD2, superoxide dismutase from Perkinsus marinus

PDB ID 2cw3

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