This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2gl8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /> <applet load="2gl8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gl8, resolution 2.40&Aring;" /> '''Human Retinoic acid...)
Current revision (09:43, 30 August 2023) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2gl8.gif|left|200px]]<br />
 
-
<applet load="2gl8" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2gl8, resolution 2.40&Aring;" />
 
-
'''Human Retinoic acid receptor RXR-gamma ligand-binding domain'''<br />
 
-
==About this Structure==
+
==Human Retinoic acid receptor RXR-gamma ligand-binding domain==
-
2GL8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GL8 OCA].
+
<StructureSection load='2gl8' size='340' side='right'caption='[[2gl8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Single protein]]
+
<table><tr><td colspan='2'>[[2gl8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GL8 FirstGlance]. <br>
-
[[Category: Arrowsmith, C.H.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
[[Category: Bochkarev, A.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gl8 OCA], [https://pdbe.org/2gl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gl8 RCSB], [https://www.ebi.ac.uk/pdbsum/2gl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gl8 ProSAT]</span></td></tr>
-
[[Category: Edwards, A.M.]]
+
</table>
-
[[Category: Loppnau, P.]]
+
== Function ==
-
[[Category: Min, J.R.]]
+
[https://www.uniprot.org/uniprot/RXRG_HUMAN RXRG_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
-
[[Category: Plotnikov, A.N.]]
+
== Evolutionary Conservation ==
-
[[Category: SGC, Structural.Genomics.Consortium.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Schuetz, A.]]
+
Check<jmol>
-
[[Category: Sundstrom, M.]]
+
<jmolCheckbox>
-
[[Category: Weigelt, J.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/2gl8_consurf.spt"</scriptWhenChecked>
-
[[Category: nuclear receptor]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: sgc]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: structural genomics]]
+
</jmolCheckbox>
-
[[Category: structural genomics consortium]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gl8 ConSurf].
 +
<div style="clear:both"></div>
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:19:55 2007''
+
==See Also==
 +
*[[Retinoid X receptor 3D structures|Retinoid X receptor 3D structures]]
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith CH]]
 +
[[Category: Bochkarev A]]
 +
[[Category: Edwards AM]]
 +
[[Category: Loppnau P]]
 +
[[Category: Min JR]]
 +
[[Category: Plotnikov AN]]
 +
[[Category: Schuetz A]]
 +
[[Category: Sundstrom M]]
 +
[[Category: Weigelt J]]

Current revision

Human Retinoic acid receptor RXR-gamma ligand-binding domain

PDB ID 2gl8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gl8"
Personal tools