2gs3

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(New page: 200px<br /> <applet load="2gs3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gs3, resolution 1.90&Aring;" /> '''Crystal structure o...)
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[[Image:2gs3.gif|left|200px]]<br />
 
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<applet load="2gs3" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2gs3, resolution 1.90&Aring;" />
 
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'''Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)'''<br />
 
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==About this Structure==
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==Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)==
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2GS3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GS3 OCA].
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<StructureSection load='2gs3' size='340' side='right'caption='[[2gs3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Phospholipid-hydroperoxide glutathione peroxidase]]
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<table><tr><td colspan='2'>[[2gs3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GS3 FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Arrowsmith, C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Delft, F.Von.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gs3 OCA], [https://pdbe.org/2gs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gs3 RCSB], [https://www.ebi.ac.uk/pdbsum/2gs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gs3 ProSAT]</span></td></tr>
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[[Category: Edwards, A.]]
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</table>
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[[Category: Gileadi, O.]]
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== Function ==
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[[Category: Johansson, C.]]
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[https://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
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[[Category: Kavanagh, K.L.]]
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== Evolutionary Conservation ==
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[[Category: Oppermann, U.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Rojkova, A.]]
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Check<jmol>
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[[Category: SGC, Structural.Genomics.Consortium.]]
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<jmolCheckbox>
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[[Category: Sundstrom, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gs3_consurf.spt"</scriptWhenChecked>
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[[Category: Weigelt, J.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: CL]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: gpx4]]
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</jmolCheckbox>
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[[Category: gshpx-4]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gs3 ConSurf].
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[[Category: phospholipid hydroperoxide]]
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<div style="clear:both"></div>
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:21:58 2007''
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==See Also==
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*[[Glutathione peroxidase|Glutathione peroxidase]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards A]]
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[[Category: Gileadi O]]
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[[Category: Johansson C]]
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[[Category: Kavanagh KL]]
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[[Category: Oppermann U]]
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[[Category: Rojkova A]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt J]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)

PDB ID 2gs3

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