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2gsb

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(New page: 200px<br /> <applet load="2gsb" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gsb" /> '''Solution structure of the second SH2 domain...)
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[[Image:2gsb.gif|left|200px]]<br />
 
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<applet load="2gsb" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2gsb" />
 
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'''Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1'''<br />
 
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==Disease==
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==Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1==
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Known diseases associated with this structure: Basal cell carcinoma, somatic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=139150 139150]], Capillary malformation-arteriovenous malformation OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=139150 139150]], Parkes Weber syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=139150 139150]]
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<StructureSection load='2gsb' size='340' side='right'caption='[[2gsb]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gsb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GSB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsb OCA], [https://pdbe.org/2gsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gsb RCSB], [https://www.ebi.ac.uk/pdbsum/2gsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gsb ProSAT], [https://www.topsan.org/Proteins/RSGI/2gsb TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/RASA1_HUMAN RASA1_HUMAN] Note=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas. Defects in RASA1 are the cause of capillary malformation-arteriovenous malformation (CMAVM) [MIM:[https://omim.org/entry/608354 608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.<ref>PMID:14639529</ref> Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:[https://omim.org/entry/608355 608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
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== Function ==
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[https://www.uniprot.org/uniprot/RASA1_HUMAN RASA1_HUMAN] Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1.<ref>PMID:8360177</ref> <ref>PMID:11389730</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gsb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gsb ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2GSB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GSB OCA].
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*[[Ras GTPase activating protein|Ras GTPase activating protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hayashi, F.]]
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[[Category: Hayashi F]]
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[[Category: Kurosaki, C.]]
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[[Category: Kurosaki C]]
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[[Category: Suetake T]]
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[[Category: Suetake, T.]]
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[[Category: Yokoyma S]]
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[[Category: Yokoyma, S.]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M.]]
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[[Category: gap]]
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[[Category: gtpase-activating protein]]
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[[Category: national project on protein structural and functional analyses]]
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[[Category: nppsfa]]
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[[Category: p120gap]]
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[[Category: ras p21 protein activator]]
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[[Category: rasgap]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:22:07 2007''
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Current revision

Solution structure of the second SH2 domain of human Ras GTPase-activating protein 1

PDB ID 2gsb

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