2h1s

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(New page: 200px<br /> <applet load="2h1s" size="450" color="white" frame="true" align="right" spinBox="true" caption="2h1s, resolution 2.45&Aring;" /> '''Crystal Structure o...)
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[[Image:2h1s.gif|left|200px]]<br />
 
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<applet load="2h1s" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2h1s, resolution 2.45&Aring;" />
 
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'''Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens'''<br />
 
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==Disease==
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==Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens==
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Known diseases associated with this structure: Hyperoxaluria, primary, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=604296 604296]]
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<StructureSection load='2h1s' size='340' side='right'caption='[[2h1s]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2h1s]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H1S FirstGlance]. <br>
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2H1S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Glyoxylate_reductase_(NADP(+)) Glyoxylate reductase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.79 1.1.1.79] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2H1S OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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[[Category: Glyoxylate reductase (NADP(+))]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h1s OCA], [https://pdbe.org/2h1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h1s RCSB], [https://www.ebi.ac.uk/pdbsum/2h1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h1s ProSAT], [https://www.topsan.org/Proteins/CESG/2h1s TOPSAN]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN] Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:[https://omim.org/entry/260000 260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.<ref>PMID:10484776</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/GRHPR_HUMAN GRHPR_HUMAN] Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/2h1s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h1s ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bingman, C.A.]]
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[[Category: Bingman CA]]
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[[Category: Bitto, E.]]
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[[Category: Bitto E]]
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[[Category: CESG, Center.for.Eukaryotic.Structural.Genomics.]]
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[[Category: Phillips Jr GN]]
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[[Category: Jr., G.N.Phillips.]]
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[[Category: Wesenberg GE]]
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[[Category: Wesenberg, G.E.]]
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[[Category: center for eukaryotic structural genomics]]
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[[Category: cesg]]
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[[Category: glyoxylate reductase]]
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[[Category: hydroxypyruvate reductase]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: q9ubq7]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:24:56 2007''
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Current revision

Crystal Structure of a Glyoxylate/Hydroxypyruvate reductase from Homo sapiens

PDB ID 2h1s

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