2dhn

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[[Image:2dhn.gif|left|200px]]
 
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==COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_2dhn", creates the "Structure Box" on the page.
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<StructureSection load='2dhn' size='340' side='right'caption='[[2dhn]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DHN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PH2:2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE'>PH2</scene></td></tr>
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{{STRUCTURE_2dhn| PDB=2dhn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dhn OCA], [https://pdbe.org/2dhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dhn RCSB], [https://www.ebi.ac.uk/pdbsum/2dhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dhn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FOLB_STAAU FOLB_STAAU] Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/2dhn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dhn ConSurf].
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<div style="clear:both"></div>
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'''COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION'''
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==See Also==
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Dihydroneopterin aldolase catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin during the de novo synthesis of folic acid from guanosine triphosphate. The gene encoding the dihydroneopterin aldolase from S. aureus has been cloned, sequenced and expressed in Escherichia coli. The protein has been purified for biochemical characterization and its X-ray structure determined at 1.65 A resolution. The protein forms an octamer of 110,000 Mr molecular weight. Four molecules assemble into a ring, and two rings come together to give a cylinder with a hole of at least 13 A diameter. The structure of the binary complex with the product 6-hydroxymethyl-7,8-dihydropterin has defined the location of the active site. The structural information and results of site directed mutagenesis allow an enzyme reaction mechanism to be proposed.
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[[Category: Large Structures]]
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==About this Structure==
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2DHN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DHN OCA].
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==Reference==
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Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus., Hennig M, D'Arcy A, Hampele IC, Page MG, Oefner C, Dale GE, Nat Struct Biol. 1998 May;5(5):357-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9586996 9586996]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Arcy, A D.]]
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[[Category: D'Arcy A]]
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[[Category: Dale, G.]]
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[[Category: Dale G]]
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[[Category: Hampele, I C.]]
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[[Category: Hampele IC]]
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[[Category: Hennig, M.]]
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[[Category: Hennig M]]
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[[Category: Oefner, C H.]]
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[[Category: Oefner CH]]
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[[Category: Page, M G.P.]]
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[[Category: Page MGP]]
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[[Category: Antibiotic target]]
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[[Category: Beta-barrel]]
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[[Category: Folate biosynthesis]]
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[[Category: Product complex]]
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[[Category: Pterine binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:26:53 2008''
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Current revision

COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION

PDB ID 2dhn

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