This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2dm4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:43, 29 May 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2dm4.gif|left|200px]]
 
-
<!--
+
==Solution structure of the second fn3 domain of human sorLA/LR11==
-
The line below this paragraph, containing "STRUCTURE_2dm4", creates the "Structure Box" on the page.
+
<StructureSection load='2dm4' size='340' side='right'caption='[[2dm4]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2dm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DM4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dm4 OCA], [https://pdbe.org/2dm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dm4 RCSB], [https://www.ebi.ac.uk/pdbsum/2dm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dm4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2dm4 TOPSAN]</span></td></tr>
-
{{STRUCTURE_2dm4| PDB=2dm4 | SCENE= }}
+
</table>
-
 
+
== Function ==
-
'''Solution structure of the second fn3 domain of human sorLA/LR11'''
+
[https://www.uniprot.org/uniprot/SORL_HUMAN SORL_HUMAN] Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction.
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==Disease==
+
Check<jmol>
-
Known disease associated with this structure: Alzheimer disease, pathogenesis, association with OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602005 602005]]
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/2dm4_consurf.spt"</scriptWhenChecked>
-
==About this Structure==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
2DM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DM4 OCA].
+
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dm4 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hayashi, F.]]
+
[[Category: Hayashi F]]
-
[[Category: Kurosaki, C.]]
+
[[Category: Kurosaki C]]
-
[[Category: Nagashima, T.]]
+
[[Category: Nagashima T]]
-
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+
[[Category: Yokoyama S]]
-
[[Category: Yokoyama, S.]]
+
[[Category: Yoshida M]]
-
[[Category: Yoshida, M.]]
+
-
[[Category: Alzheimer's disease]]
+
-
[[Category: App]]
+
-
[[Category: Bace1]]
+
-
[[Category: Beta-sandwich]]
+
-
[[Category: Low-density lipoprotein receptor relative with 11 ligand-binding repeat]]
+
-
[[Category: Lr11]]
+
-
[[Category: National project on protein structural and functional analyse]]
+
-
[[Category: Nppsfa]]
+
-
[[Category: Riken structural genomics/proteomics initiative]]
+
-
[[Category: Rsgi]]
+
-
[[Category: Sorla]]
+
-
[[Category: Sorting protein-related receptor containing ldlr class a repeat]]
+
-
[[Category: Structural genomic]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:43:22 2008''
+

Current revision

Solution structure of the second fn3 domain of human sorLA/LR11

PDB ID 2dm4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dm4"
Personal tools