2dmw

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[[Image:2dmw.gif|left|200px]]
 
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==Solution structure of the LONGIN domain of Synaptobrevin-like protein 1==
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The line below this paragraph, containing "STRUCTURE_2dmw", creates the "Structure Box" on the page.
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<StructureSection load='2dmw' size='340' side='right'caption='[[2dmw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dmw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DMW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dmw OCA], [https://pdbe.org/2dmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dmw RCSB], [https://www.ebi.ac.uk/pdbsum/2dmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dmw ProSAT], [https://www.topsan.org/Proteins/RSGI/2dmw TOPSAN]</span></td></tr>
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{{STRUCTURE_2dmw| PDB=2dmw | SCENE= }}
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</table>
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== Disease ==
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'''Solution structure of the LONGIN domain of Synaptobrevin-like protein 1'''
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[https://www.uniprot.org/uniprot/VAMP7_HUMAN VAMP7_HUMAN] 46,XY partial gonadal dysgenesis.
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== Function ==
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[https://www.uniprot.org/uniprot/VAMP7_HUMAN VAMP7_HUMAN] Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.<ref>PMID:10888671</ref> <ref>PMID:16677249</ref> <ref>PMID:18042464</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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2DMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DMW OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/2dmw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dmw ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: Ohnishi, S.]]
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[[Category: Ohnishi S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sato M]]
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[[Category: Sato, M.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Longin domain]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:46:26 2008''
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Current revision

Solution structure of the LONGIN domain of Synaptobrevin-like protein 1

PDB ID 2dmw

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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