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2doo

From Proteopedia

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[[Image:2doo.jpg|left|200px]]
 
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==The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe==
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The line below this paragraph, containing "STRUCTURE_2doo", creates the "Structure Box" on the page.
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<StructureSection load='2doo' size='340' side='right'caption='[[2doo]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2doo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DOO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C4H:N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE'>C4H</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2doo| PDB=2doo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2doo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2doo OCA], [https://pdbe.org/2doo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2doo RCSB], [https://www.ebi.ac.uk/pdbsum/2doo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2doo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/2doo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2doo ConSurf].
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<div style="clear:both"></div>
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'''The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe'''
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==See Also==
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2DOO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DOO OCA].
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[[Category: Large Structures]]
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==Reference==
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Probing, inhibition, and crystallographic characterization of metallo-beta-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups., Kurosaki H, Yamaguchi Y, Yasuzawa H, Jin W, Yamagata Y, Arakawa Y, ChemMedChem. 2006 Sep;1(9):969-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16937423 16937423]
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[[Category: Beta-lactamase]]
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[[Category: Serratia marcescens]]
[[Category: Serratia marcescens]]
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[[Category: Single protein]]
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[[Category: Arakawa Y]]
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[[Category: Arakawa, Y.]]
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[[Category: Jin W]]
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[[Category: Jin, W.]]
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[[Category: Kurosaki H]]
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[[Category: Kurosaki, H.]]
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[[Category: Yamagata Y]]
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[[Category: Yamagata, Y.]]
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[[Category: Yamaguchi Y]]
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[[Category: Yamaguchi, Y.]]
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[[Category: Yasuzawa H]]
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[[Category: Yasuzawa, H.]]
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[[Category: Metallo-beta-lactamase]]
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[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 00:53:27 2008''
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Current revision

The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe

PDB ID 2doo

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