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2dxe

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[[Image:2dxe.jpg|left|200px]]
 
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==Crystal structure of nucleoside diphosphate kinase in complex with GDP==
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The line below this paragraph, containing "STRUCTURE_2dxe", creates the "Structure Box" on the page.
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<StructureSection load='2dxe' size='340' side='right'caption='[[2dxe]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2dxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DXE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2dxe| PDB=2dxe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dxe OCA], [https://pdbe.org/2dxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dxe RCSB], [https://www.ebi.ac.uk/pdbsum/2dxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dxe ProSAT], [https://www.topsan.org/Proteins/RSGI/2dxe TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NDK_PYRHO NDK_PYRHO] Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dx/2dxe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dxe ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of nucleoside diphosphate kinase in complex with GDP'''
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==See Also==
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*[[Nucleoside diphosphate kinase 3D structures|Nucleoside diphosphate kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2DXE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DXE OCA].
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[[Category: Large Structures]]
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[[Category: Nucleoside-diphosphate kinase]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Kato-Murayama M]]
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[[Category: Single protein]]
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[[Category: Murayama K]]
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[[Category: Kato-Murayama, M.]]
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[[Category: Shirouzu M]]
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[[Category: Murayama, K.]]
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[[Category: Terada T]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Yokoyama S]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: Kinase]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Nucleoside binding]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:34:00 2008''
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Current revision

Crystal structure of nucleoside diphosphate kinase in complex with GDP

PDB ID 2dxe

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