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| - | [[Image:2hlb.gif|left|200px]]<br />
| + | <table cellpadding='5'><tr><td style='background-color: yellow;border:2px solid black;font-size:150%;'> |
| - | <applet load="2hlb" size="450" color="white" frame="true" align="right" spinBox="true" | + | NOTE: This structure was removed. For additional information see '''2012, January:''' at [[Retractions and Fraud]].</td></tr></table> |
| - | caption="2hlb, resolution 2.2Å" />
| + | REMOVED: The PDB entry 2hlb was removed. |
| - | '''A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity'''<br /> | + | |
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| - | ==Overview==
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| - | Heterotrimeric G proteins are molecular switches that relay information, intracellularly in response to various extracellular signals. How, ligand-activated G protein-coupled receptors act at a distance to exert, exchange activity on the Galpha nucleotide binding pocket is poorly, understood. Here we describe the synergistic action of two peptides: one, from the third intracellular loop of the D2 dopamine receptor (D2N), and a, second, Galpha.GDP-binding peptide (KB-752) that mimics the proposed role, of Gbetagamma in receptor-promoted nucleotide exchange. The structure of, both peptides in complex with Galpha(i1) suggests that conformational, changes in the beta3/alpha2 loop and beta6 strand act in concert for, efficient nucleotide exchange. Two key residues in the alpha4 helix were, found to define a receptor/Galpha(i) coupling specificity determinant.
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| - | ==Disease==
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| - | Known disease associated with this structure: Dystonia, myoclonic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126450 126450]]
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| - | ==About this Structure==
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| - | 2HLB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GDP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HLB OCA].
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| - | ==Reference==
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| - | Structural basis for nucleotide exchange on Galphai subunits and receptor coupling specificity., Johnston CA, Siderovski DP, Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17264214 17264214]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Protein complex]]
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| - | [[Category: Johnston, C.A.]]
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| - | [[Category: Siderovski, D.P.]]
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| - | [[Category: Watts, V.J.]]
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| - | [[Category: GDP]]
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| - | [[Category: SO4]]
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| - | [[Category: protein:peptide complex]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:33:49 2007''
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