2hup

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(New page: 200px<br /> <applet load="2hup" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hup, resolution 2.050&Aring;" /> '''Crystal structure ...)
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[[Image:2hup.gif|left|200px]]<br />
 
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<applet load="2hup" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2hup, resolution 2.050&Aring;" />
 
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'''Crystal structure of human RAB43 in complex with GDP'''<br />
 
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==About this Structure==
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==Crystal structure of human RAB43 in complex with GDP==
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2HUP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, GDP and UNX as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2HUP OCA].
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<StructureSection load='2hup' size='340' side='right'caption='[[2hup]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2hup]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HUP FirstGlance]. <br>
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[[Category: Arrowsmith, C.H.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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[[Category: Bochkarev, A.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Edwards, A.M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hup OCA], [https://pdbe.org/2hup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hup RCSB], [https://www.ebi.ac.uk/pdbsum/2hup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hup ProSAT]</span></td></tr>
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[[Category: Landry, R.]]
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</table>
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[[Category: Park, H.]]
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== Function ==
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[[Category: SGC, Structural.Genomics.Consortium.]]
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[https://www.uniprot.org/uniprot/RAB43_HUMAN RAB43_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17562788</ref> <ref>PMID:17684057</ref> <ref>PMID:18664496</ref> <ref>PMID:21255211</ref>
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[[Category: Shen, Y.]]
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== Evolutionary Conservation ==
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[[Category: Sundstrom, M.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Tempel, W.]]
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Check<jmol>
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[[Category: Wang, J.]]
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<jmolCheckbox>
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[[Category: Weigelt, J.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/2hup_consurf.spt"</scriptWhenChecked>
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[[Category: GDP]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: MG]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: UNX]]
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</jmolCheckbox>
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[[Category: g-protein]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hup ConSurf].
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[[Category: gdp]]
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<div style="clear:both"></div>
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[[Category: rab]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:36:25 2007''
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev A]]
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[[Category: Edwards AM]]
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[[Category: Landry R]]
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[[Category: Park H]]
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[[Category: Shen Y]]
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[[Category: Sundstrom M]]
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[[Category: Tempel W]]
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[[Category: Wang J]]
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[[Category: Weigelt J]]

Current revision

Crystal structure of human RAB43 in complex with GDP

PDB ID 2hup

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