2f0c

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[[Image:2f0c.gif|left|200px]]
 
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==Structure of the Receptor Binding Protein (ORF49, bbp) from lactophage tp901-1==
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The line below this paragraph, containing "STRUCTURE_2f0c", creates the "Structure Box" on the page.
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<StructureSection load='2f0c' size='340' side='right'caption='[[2f0c]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f0c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_phage_TP901-1 Lactococcus phage TP901-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F0C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2f0c| PDB=2f0c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f0c OCA], [https://pdbe.org/2f0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f0c RCSB], [https://www.ebi.ac.uk/pdbsum/2f0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f0c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9G096_9CAUD Q9G096_9CAUD]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/2f0c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f0c ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lactococcus lactis is a gram-positive bacterium widely used by the dairy industry. Several industrial L. lactis strains are sensitive to various distinct bacteriophages. Most of them belong to the Siphoviridae family and comprise several species, among which the 936 and P335 are prominent. Members of these two phage species recognize their hosts through the interaction of their receptor-binding protein (RBP) with external cell wall saccharidices of the host, the "receptors." We report here the 1.65 A resolution crystal structure of the RBP from phage TP901-1, a member of the P335 species. This RBP of 163 amino acids is a homotrimer comprising three domains: a helical N terminus, an interlaced beta-prism, and a beta-barrel, the head domain (residues 64-163), which binds a glycerol molecule. Fluorescence quenching experiments indicated that the RBP exhibits high affinity for glycerol, muramyl-dipeptide, and other saccharides in solution. The structural comparison of this RBP with that of lactococcal phage p2 RBP, a member of the 936 species (Spinelli, S., Desmyter, A., Verrips, C. T., de Haard, J. W., Moineau, S., and Cambillau, C. (2006) Nat. Struct. Mol. Biol. 13, 85-89) suggests a large extent of modularity in RBPs of lactococcal phages.
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'''Structure of the Receptor Binding Protein (ORF49, bbp) from lactophage tp901-1'''
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Modular structure of the receptor binding proteins of Lactococcus lactis phages. The RBP structure of the temperate phage TP901-1.,Spinelli S, Campanacci V, Blangy S, Moineau S, Tegoni M, Cambillau C J Biol Chem. 2006 May 19;281(20):14256-62. Epub 2006 Mar 20. PMID:16549427<ref>PMID:16549427</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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2F0C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_phage_tp901-1 Lactococcus phage tp901-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F0C OCA].
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<div class="pdbe-citations 2f0c" style="background-color:#fffaf0;"></div>
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[[Category: Lactococcus phage tp901-1]]
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== References ==
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[[Category: Single protein]]
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<references/>
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[[Category: Cambillau, C.]]
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__TOC__
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[[Category: Spinelli, S.]]
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</StructureSection>
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[[Category: 3 helix parallel bundle]]
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[[Category: Lactococcus phage TP901-1]]
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[[Category: Beta prism]]
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[[Category: Large Structures]]
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[[Category: Beta-barrel]]
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[[Category: Cambillau C]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:18:42 2008''
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[[Category: Spinelli S]]

Current revision

Structure of the Receptor Binding Protein (ORF49, bbp) from lactophage tp901-1

PDB ID 2f0c

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