2f3n

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[[Image:2f3n.gif|left|200px]]
 
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==Crystal Structure of the native Shank SAM domain.==
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The line below this paragraph, containing "STRUCTURE_2f3n", creates the "Structure Box" on the page.
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<StructureSection load='2f3n' size='340' side='right'caption='[[2f3n]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f3n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3n OCA], [https://pdbe.org/2f3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3n RCSB], [https://www.ebi.ac.uk/pdbsum/2f3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3n ProSAT]</span></td></tr>
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{{STRUCTURE_2f3n| PDB=2f3n | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SHAN3_RAT SHAN3_RAT] Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f3n ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of the native Shank SAM domain.'''
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==See Also==
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*[[Shank protein|Shank protein]]
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__TOC__
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==Overview==
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</StructureSection>
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The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.
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[[Category: Large Structures]]
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==About this Structure==
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2F3N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3N OCA].
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==Reference==
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An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16439662 16439662]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Baron MK]]
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[[Category: Baron, M K.]]
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[[Category: Bowie JU]]
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[[Category: Bowie, J U.]]
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[[Category: Faham S]]
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[[Category: Faham, S.]]
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[[Category: Postsynaptic density]]
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[[Category: Sam domain]]
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[[Category: Scaffolding protein]]
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[[Category: Shank]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:25:29 2008''
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Current revision

Crystal Structure of the native Shank SAM domain.

PDB ID 2f3n

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