2f4e

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[[Image:2f4e.gif|left|200px]]
 
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==N-terminal domain of FKBP42 from Arabidopsis thaliana==
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The line below this paragraph, containing "STRUCTURE_2f4e", creates the "Structure Box" on the page.
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<StructureSection load='2f4e' size='340' side='right'caption='[[2f4e]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f4e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F4E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f4e OCA], [https://pdbe.org/2f4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f4e RCSB], [https://www.ebi.ac.uk/pdbsum/2f4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f4e ProSAT]</span></td></tr>
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{{STRUCTURE_2f4e| PDB=2f4e | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FKB42_ARATH FKB42_ARATH] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Modulates the uptake of MRP substrates into the vacuole; reduces metolachlor-GS (MOC-GS) and enhances 17-beta-estradiol 17-(beta-D-glucuronide) (E(2)17betaG) uptake. Regulates cell elongation and orientation. Functions as a positive regulator of PGP1-mediated auxin transport. Confers drug modulation of PGP1 efflux activity as interaction with NPA or flavonol quercetin prevents its physical and functional interaction with PGP1. Required for the proper localization of auxin-related ABCB transporters. Plays a role in brassinosteroid (BR) signaling pathway.<ref>PMID:14517332</ref> <ref>PMID:15133126</ref> <ref>PMID:14730066</ref> <ref>PMID:16887800</ref> <ref>PMID:18499676</ref> <ref>PMID:20971896</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f4/2f4e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f4e ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present the three-dimensional structure of the N-terminal FK506-binding protein (FKBP)-like domain of the immunophilin FKBP42 from Arabidopsis thaliana. The data provide the structural background for the explanation of key functional properties reported previously.
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'''N-terminal domain of FKBP42 from Arabidopsis thaliana'''
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Crystal structure of a plant immunophilin domain involved in regulation of MDR-type ABC transporters.,Weiergraber OH, Eckhoff A, Granzin J FEBS Lett. 2006 Jan 9;580(1):251-5. Epub 2005 Dec 12. PMID:16364310<ref>PMID:16364310</ref>
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==Overview==
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We present the three-dimensional structure of the N-terminal FK506-binding protein (FKBP)-like domain of the immunophilin FKBP42 from Arabidopsis thaliana. The data provide the structural background for the explanation of key functional properties reported previously.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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2F4E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4E OCA].
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</div>
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<div class="pdbe-citations 2f4e" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Crystal structure of a plant immunophilin domain involved in regulation of MDR-type ABC transporters., Weiergraber OH, Eckhoff A, Granzin J, FEBS Lett. 2006 Jan 9;580(1):251-5. Epub 2005 Dec 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16364310 16364310]
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*[[FKBP 3D structures|FKBP 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Eckhoff, A.]]
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[[Category: Eckhoff A]]
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[[Category: Granzin, J.]]
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[[Category: Granzin J]]
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[[Category: Weiergraber, O H.]]
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[[Category: Weiergraber OH]]
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[[Category: Alpha-beta]]
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[[Category: Fkbp-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:26:54 2008''
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Current revision

N-terminal domain of FKBP42 from Arabidopsis thaliana

PDB ID 2f4e

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