2f6a

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[[Image:2f6a.jpg|left|200px]]
 
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==Collagen Adhesin and Collagen Complex Structure==
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The line below this paragraph, containing "STRUCTURE_2f6a", creates the "Structure Box" on the page.
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<StructureSection load='2f6a' size='340' side='right'caption='[[2f6a]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f6a]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saimiriine_gammaherpesvirus_2 Saimiriine gammaherpesvirus 2] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F6A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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{{STRUCTURE_2f6a| PDB=2f6a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6a OCA], [https://pdbe.org/2f6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f6a RCSB], [https://www.ebi.ac.uk/pdbsum/2f6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f6a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CNA_STAAU CNA_STAAU] Mediates attachment of staphylococcal cells to collagen-containing substrata.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/2f6a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f6a ConSurf].
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<div style="clear:both"></div>
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'''Collagen Adhesin and Collagen Complex Structure'''
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==See Also==
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*[[Adhesin 3D structures|Adhesin 3D structures]]
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*[[Collagen 3D structures|Collagen 3D structures]]
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==Overview==
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__TOC__
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The structural basis for the association of eukaryotic and prokaryotic protein receptors and their triple-helical collagen ligand remains poorly understood. Here, we present the crystal structures of a high affinity subsegment of the Staphylococcus aureus collagen-binding CNA as an apo-protein and in complex with a synthetic collagen-like triple helical peptide. The apo-protein structure is composed of two subdomains (N1 and N2), each adopting a variant IgG-fold, and a long linker that connects N1 and N2. The structure is stabilized by hydrophobic inter-domain interactions and by the N2 C-terminal extension that complements a beta-sheet on N1. In the ligand complex, the collagen-like peptide penetrates through a spherical hole formed by the two subdomains and the N1-N2 linker. Based on these two structures we propose a dynamic, multistep binding model, called the 'Collagen Hug' that is uniquely designed to allow multidomain collagen binding proteins to bind their extended rope-like ligand.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Saimiriine gammaherpesvirus 2]]
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2F6A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6A OCA].
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==Reference==
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A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen., Zong Y, Xu Y, Liang X, Keene DR, Hook A, Gurusiddappa S, Hook M, Narayana SV, EMBO J. 2005 Dec 21;24(24):4224-36. Epub 2005 Dec 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16362049 16362049]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Narayana, S L.V.]]
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[[Category: Narayana SLV]]
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[[Category: Zong, Y.]]
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[[Category: Zong Y]]
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[[Category: Adhesion]]
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[[Category: Cna]]
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[[Category: Collagen]]
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[[Category: Ecm]]
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[[Category: Mscramm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:30:35 2008''
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Current revision

Collagen Adhesin and Collagen Complex Structure

PDB ID 2f6a

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