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2fc6

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[[Image:2fc6.gif|left|200px]]
 
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==Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)==
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The line below this paragraph, containing "STRUCTURE_2fc6", creates the "Structure Box" on the page.
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<StructureSection load='2fc6' size='340' side='right'caption='[[2fc6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FC6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2fc6| PDB=2fc6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fc6 OCA], [https://pdbe.org/2fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fc6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2fc6 TOPSAN]</span></td></tr>
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</table>
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'''Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)'''
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== Disease ==
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[https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Pontocerebellar hypoplasia type 7. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/TOE1_HUMAN TOE1_HUMAN] Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing (PubMed:28092684).<ref>PMID:12562764</ref> <ref>PMID:28092684</ref>
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2FC6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FC6 OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dang, W.]]
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[[Category: Dang W]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nmr]]
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[[Category: Nppsfa]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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[[Category: Structure genomic]]
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[[Category: Zf-ccch domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:43:04 2008''
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Current revision

Solution structure of the zf-CCCH domain of target of EGR1, member 1 (Nuclear)

PDB ID 2fc6

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