2fic

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[[Image:2fic.gif|left|200px]]
 
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==The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition==
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The line below this paragraph, containing "STRUCTURE_2fic", creates the "Structure Box" on the page.
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<StructureSection load='2fic' size='340' side='right'caption='[[2fic]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FIC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XE:XENON'>XE</scene></td></tr>
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{{STRUCTURE_2fic| PDB=2fic | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fic OCA], [https://pdbe.org/2fic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fic RCSB], [https://www.ebi.ac.uk/pdbsum/2fic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fic ProSAT]</span></td></tr>
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</table>
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'''The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition'''
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== Disease ==
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[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN] Defects in BIN1 are the cause of centronuclear myopathy type 2 (CNM2) [MIM:[https://omim.org/entry/255200 255200]. A congenital muscle disorder characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.<ref>PMID:17676042</ref>
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== Function ==
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==Overview==
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[https://www.uniprot.org/uniprot/BIN1_HUMAN BIN1_HUMAN] May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
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BAR domains are found in proteins that bind and remodel membranes and participate in cytoskeletal and nuclear processes. Here, we report the crystal structure of the BAR domain from the human Bin1 protein at 2.0 A resolution. Both the quaternary and tertiary architectures of the homodimeric Bin1BAR domain are built upon "knobs-into-holes" packing of side chains, like those found in conventional left-handed coiled-coils, and this packing governs the curvature of a putative membrane-engaging concave face. Our calculations indicate that the Bin1BAR domain contains two potential sites for protein-protein interactions on the convex face of the dimer. Comparative analysis of structural features reveals that at least three architectural subtypes of the BAR domain are encoded in the human genome, represented by the Arfaptin, Bin1/Amphiphysin, and IRSp53 BAR domains. We discuss how these principal groups may differ in their potential to form regulatory heterotypic interactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2FIC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIC OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/2fic_consurf.spt"</scriptWhenChecked>
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==Reference==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition., Casal E, Federici L, Zhang W, Fernandez-Recio J, Priego EM, Miguel RN, DuHadaway JB, Prendergast GC, Luisi BF, Laue ED, Biochemistry. 2006 Oct 31;45(43):12917-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17059209 17059209]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fic ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Casal, E.]]
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[[Category: Casal E]]
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[[Category: Duhadaway, J B.]]
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[[Category: Duhadaway JB]]
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[[Category: Federici, L.]]
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[[Category: Federici L]]
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[[Category: Fernandez-Recio, J.]]
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[[Category: Fernandez-Recio J]]
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[[Category: Laue, E D.]]
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[[Category: Laue ED]]
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[[Category: Luisi, B F.]]
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[[Category: Luisi BF]]
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[[Category: Miguel, R N.]]
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[[Category: Miguel RN]]
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[[Category: Prendergast, G C.]]
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[[Category: Prendergast GC]]
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[[Category: Priego, E M.]]
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[[Category: Priego EM]]
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[[Category: Zhang, W.]]
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[[Category: Zhang W]]
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[[Category: Bar domain]]
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[[Category: Coiled-coil]]
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[[Category: Homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:55:55 2008''
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Current revision

The crystal structure of the BAR domain from human Bin1/Amphiphysin II and its implications for molecular recognition

PDB ID 2fic

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