2fjt

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[[Image:2fjt.gif|left|200px]]
 
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==Adenylyl cyclase class iv from Yersinia pestis==
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The line below this paragraph, containing "STRUCTURE_2fjt", creates the "Structure Box" on the page.
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<StructureSection load='2fjt' size='340' side='right'caption='[[2fjt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fjt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis_KIM10+ Yersinia pestis KIM10+]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2fjt| PDB=2fjt | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fjt OCA], [https://pdbe.org/2fjt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fjt RCSB], [https://www.ebi.ac.uk/pdbsum/2fjt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fjt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A5P8YEL9_YERPE A0A5P8YEL9_YERPE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/2fjt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fjt ConSurf].
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<div style="clear:both"></div>
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'''Adenylyl cyclase class iv from Yersinia pestis'''
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==See Also==
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*[[3D Adenylyl cyclase 3D structures|3D Adenylyl cyclase 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The crystal structure of the class IV adenylyl cyclase (AC) from Yersinia pestis (Yp) is reported at 1.9 A resolution. The class IV AC fold is distinct from the previously described folds for class II and class III ACs. The dimeric AC-IV folds into an antiparallel eight-stranded barrel whose connectivity has been seen in only three previous structures: yeast RNA triphosphatase and two proteins of unknown function from Pyrococcus furiosus and Vibrio parahaemolyticus. Eight highly conserved ionic residues E10, E12, K14, R63, K76, K111, D126, and E136 lie in the barrel core and form the likely binding sites for substrate and divalent cations. A phosphate ion is observed bound to R63, K76, K111, and R113 near the center of the conserved cluster. Unlike the AC-II and AC-III active sites that utilize two-Asp motifs for cation binding, the AC-IV active site is relatively enriched in glutamate and features an ExE motif as its most conserved element. Homologs of Y. pestis AC-IV, including human thiamine triphosphatase, span the three kingdoms of life and delineate an ancient family of phosphonucleotide processing enzymes.
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[[Category: Large Structures]]
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[[Category: Yersinia pestis KIM10+]]
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==About this Structure==
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[[Category: Gallagher DT]]
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2FJT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJT OCA].
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[[Category: Heroux A]]
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[[Category: Kim S-K]]
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==Reference==
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[[Category: Reddy PT]]
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Structure of the class IV adenylyl cyclase reveals a novel fold., Gallagher DT, Smith NN, Kim SK, Heroux A, Robinson H, Reddy PT, J Mol Biol. 2006 Sep 8;362(1):114-22. Epub 2006 Aug 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16905149 16905149]
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[[Category: Robinson H]]
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[[Category: Adenylate cyclase]]
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[[Category: Smith NN]]
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[[Category: Single protein]]
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[[Category: Yersinia pestis]]
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[[Category: Gallagher, D T.]]
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[[Category: Heroux, A.]]
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[[Category: Kim, S K.]]
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[[Category: Reddy, P T.]]
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[[Category: Robinson, H.]]
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[[Category: Smith, N N.]]
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[[Category: Beta barrel]]
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[[Category: Cyclase]]
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[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:58:52 2008''
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Current revision

Adenylyl cyclase class iv from Yersinia pestis

PDB ID 2fjt

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