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2fkd

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[[Image:2fkd.gif|left|200px]]
 
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==Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor==
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The line below this paragraph, containing "STRUCTURE_2fkd", creates the "Structure Box" on the page.
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<StructureSection load='2fkd' size='340' side='right'caption='[[2fkd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fkd]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_186 Escherichia virus 186]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FKD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fkd OCA], [https://pdbe.org/2fkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fkd RCSB], [https://www.ebi.ac.uk/pdbsum/2fkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fkd ProSAT]</span></td></tr>
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{{STRUCTURE_2fkd| PDB=2fkd | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor'''
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[https://www.uniprot.org/uniprot/RPC1_BP186 RPC1_BP186] Repressor of lysogeny.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Bacteriophage lambda is a paradigm for understanding the role of cooperativity in gene regulation. Comparison of the regulatory regions of lambda and the unrelated temperate bacteriophage 186 provides insight into alternate ways to assemble functional genetic switches. The structure of the C-terminal domain of the 186 repressor, determined at 2.7 A resolution, reveals an unusual heptamer of dimers, consistent with presented genetic studies. In addition, the structure of a cooperativity mutant of the full-length 186 repressor, identified by genetic screens, was solved to 1.95 A resolution. These structures provide a molecular basis for understanding lysogenic regulation in 186. Whereas the overall fold of the 186 and lambda repressor monomers is remarkably similar, the way the two repressors cooperatively assemble is quite different and explains in part the differences in their regulatory activity.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/2fkd_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2FKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_186 Enterobacteria phage 186]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKD OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fkd ConSurf].
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The structural basis of cooperative regulation at an alternate genetic switch., Pinkett HW, Shearwin KE, Stayrook S, Dodd IB, Burr T, Hochschild A, Egan JB, Lewis M, Mol Cell. 2006 Mar 3;21(5):605-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16507359 16507359]
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<div style="clear:both"></div>
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[[Category: Enterobacteria phage 186]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Lewis, M.]]
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[[Category: Escherichia virus 186]]
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[[Category: Cooperativity]]
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[[Category: Large Structures]]
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[[Category: Genetic switch]]
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[[Category: Lewis M]]
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[[Category: Regulation]]
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[[Category: Repressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:59:54 2008''
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Current revision

Crystal Structure of the C-terminal domain of Bacteriophage 186 repressor

PDB ID 2fkd

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