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2jii
From Proteopedia
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| - | [[Image:2jii.gif|left|200px]]<br /> | ||
| - | <applet load="2jii" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2jii, resolution 2.00Å" /> | ||
| - | '''STRUCTURE OF VACCINIA RELATED KINASE 3'''<br /> | ||
| - | == | + | ==Structure of vaccinia related kinase 3== |
| - | + | <StructureSection load='2jii' size='340' side='right'caption='[[2jii]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2jii]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JII FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jii OCA], [https://pdbe.org/2jii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jii RCSB], [https://www.ebi.ac.uk/pdbsum/2jii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jii ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VRK3_HUMAN VRK3_HUMAN] Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.<ref>PMID:14645249</ref> <ref>PMID:19141289</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jii_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jii ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Arrowsmith CH]] | |
| - | [[Category: Arrowsmith | + | [[Category: Bunkoczi G]] |
| - | [[Category: Bunkoczi | + | [[Category: Burgess-Brown N]] |
| - | [[Category: Burgess-Brown | + | [[Category: Cooper C]] |
| - | [[Category: Cooper | + | [[Category: Edwards A]] |
| - | + | [[Category: Eswaran J]] | |
| - | [[Category: Edwards | + | [[Category: Fedorov O]] |
| - | [[Category: Eswaran | + | [[Category: Keates T]] |
| - | [[Category: Fedorov | + | [[Category: Knapp S]] |
| - | [[Category: Keates | + | [[Category: Pike ACW]] |
| - | [[Category: Knapp | + | [[Category: Salah E]] |
| - | [[Category: Pike | + | [[Category: Savitsky P]] |
| - | [[Category: Salah | + | [[Category: Sobott F]] |
| - | [[Category: Savitsky | + | [[Category: Sundstrom M]] |
| - | [[Category: Sobott | + | [[Category: Ugochukwu E]] |
| - | [[Category: Sundstrom | + | [[Category: Uppenberg J]] |
| - | [[Category: Ugochukwu | + | [[Category: Weigelt J]] |
| - | [[Category: Uppenberg | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
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Current revision
Structure of vaccinia related kinase 3
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bunkoczi G | Burgess-Brown N | Cooper C | Edwards A | Eswaran J | Fedorov O | Keates T | Knapp S | Pike ACW | Salah E | Savitsky P | Sobott F | Sundstrom M | Ugochukwu E | Uppenberg J | Weigelt J | Von Delft F
