This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jis

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:11, 5 August 2020) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2jis.gif|left|200px]]<br />
 
-
<applet load="2jis" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2jis, resolution 1.60&Aring;" />
 
-
'''HUMAN CYSTEINE SULFINIC ACID DECARBOXYLASE (CSAD) IN COMPLEX WITH PLP.'''<br />
 
-
==Disease==
+
==Human cysteine sulfinic acid decarboxylase (CSAD) in complex with PLP.==
-
Known diseases associated with this structure: Corneal dystrophy, Avellino type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601692 601692]], Corneal dystrophy, Groenouw type I OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601692 601692]], Corneal dystrophy, Reis-Bucklers type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601692 601692]], Corneal dystrophy, Thiel-Behnke type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601692 601692]], Corneal dystrophy, epithelial basement membrane OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601692 601692]], Corneal dystrophy, lattice type I OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601692 601692]], Corneal dystrophy, lattice type IIIA OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601692 601692]]
+
<StructureSection load='2jis' size='340' side='right'caption='[[2jis]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[2jis]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JIS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JIS FirstGlance]. <br>
-
2JIS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NO3 and PLP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Sulfinoalanine_decarboxylase Sulfinoalanine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.29 4.1.1.29] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JIS OCA].
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-
[[Category: Homo sapiens]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfinoalanine_decarboxylase Sulfinoalanine decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.29 4.1.1.29] </span></td></tr>
-
[[Category: Single protein]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jis OCA], [http://pdbe.org/2jis PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jis RCSB], [http://www.ebi.ac.uk/pdbsum/2jis PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jis ProSAT]</span></td></tr>
 +
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2jis_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jis ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Human]]
 +
[[Category: Large Structures]]
[[Category: Sulfinoalanine decarboxylase]]
[[Category: Sulfinoalanine decarboxylase]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith, C]]
-
[[Category: Berg, S.Van.Den.]]
+
[[Category: Berg, S van den]]
-
[[Category: Berglund, H.]]
+
[[Category: Berglund, H]]
-
[[Category: Busam, R.]]
+
[[Category: Busam, R]]
-
[[Category: Collins, R.]]
+
[[Category: Collins, R]]
-
[[Category: Dahlgren, L.G.]]
+
[[Category: Dahlgren, L G]]
-
[[Category: Edwards, A.]]
+
[[Category: Edwards, A]]
-
[[Category: Flodin, S.]]
+
[[Category: Flodin, S]]
-
[[Category: Flores, A.]]
+
[[Category: Flores, A]]
-
[[Category: Graslund, S.]]
+
[[Category: Graslund, S]]
-
[[Category: Hallberg, B.M.]]
+
[[Category: Hallberg, B M]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Hammarstrom, M]]
-
[[Category: Holmberg-Schiavone, L.]]
+
[[Category: Holmberg-Schiavone, L]]
-
[[Category: Johansson, I.]]
+
[[Category: Johansson, I]]
-
[[Category: Kallas, A.]]
+
[[Category: Kallas, A]]
-
[[Category: Karlberg, T.]]
+
[[Category: Karlberg, T]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Kotenyova, T]]
-
[[Category: Lehtio, L.]]
+
[[Category: Lehtio, L]]
-
[[Category: Moche, M.]]
+
[[Category: Moche, M]]
-
[[Category: Nordlund, P.]]
+
[[Category: Nordlund, P]]
-
[[Category: Nyman, T.]]
+
[[Category: Nyman, T]]
-
[[Category: Ogg, D.]]
+
[[Category: Ogg, D]]
-
[[Category: Persson, C.]]
+
[[Category: Persson, C]]
-
[[Category: Sagemark, J.]]
+
[[Category: Structural genomic]]
-
[[Category: Sgc, Structural GenomicsConsortium.]]
+
[[Category: Sagemark, J]]
-
[[Category: Stenmark, P.]]
+
[[Category: Stenmark, P]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Sundstrom, M]]
-
[[Category: Thorsell, A.G.]]
+
[[Category: Thorsell, A G]]
-
[[Category: Tresaugues, L.]]
+
[[Category: Tresaugues, L]]
-
[[Category: Weigelt, J.]]
+
[[Category: Weigelt, J]]
-
[[Category: Welin, M.]]
+
[[Category: Welin, M]]
-
[[Category: NO3]]
+
[[Category: Alternative splicing]]
-
[[Category: PLP]]
+
[[Category: Decarboxylase]]
-
[[Category: alternative splicing]]
+
[[Category: Lyase]]
-
[[Category: decarboxylase]]
+
[[Category: Pyridoxal phosphate]]
-
[[Category: lyase]]
+
[[Category: Vitamin b6]]
-
[[Category: pyridoxal phosphate]]
+
-
[[Category: pyridoxal phosphate (plp)]]
+
-
[[Category: structural genomics consortium (sgc)]]
+
-
[[Category: vitamin b6]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:56:13 2007''
+

Current revision

Human cysteine sulfinic acid decarboxylase (CSAD) in complex with PLP.

PDB ID 2jis

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jis"
Personal tools