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| - | [[Image:2jmq.gif|left|200px]]<br /> | + | #REDIRECT [[2k1j]] This PDB entry is obsolete and replaced by 2k1j |
| - | <applet load="2jmq" size="450" color="white" frame="true" align="right" spinBox="true"
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| - | caption="2jmq" />
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| - | '''Plant Homeodomain Finger of the tumour suppressor ING4'''<br />
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| - | ==Overview==
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| - | Plant homeodomain (PHD) fingers are frequently present in proteins, involved in chromatin remodelling, and some of them bind to histones. The, family of proteins inhibitors of growth (ING) contains a PHD finger that, bind to histone-3 trimethylated at lysine 4, and those of ING1 and ING2, also act as nuclear phosphoinositide receptors. We have determined the, structure of ING4 PHD, and characterised its binding to phosphoinositides, and histone methylated tails. In contrast to ING2, ING4 is not a, phosphoinositide receptor and binds with similar affinity to the different, methylation states of histone-3 at lysine 4.
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| - | ==About this Structure==
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| - | 2JMQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JMQ OCA].
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| - | ==Reference==
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| - | Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4., Palacios A, Garcia P, Padro D, Lopez-Hernandez E, Martin I, Blanco FJ, FEBS Lett. 2006 Dec 22;580(30):6903-8. Epub 2006 Nov 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17157298 17157298]
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Single protein]]
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| - | [[Category: Blanco, F.J.]]
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| - | [[Category: Garcia, P.]]
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| - | [[Category: Lopez-Hernandez, E.]]
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| - | [[Category: Padro, D.]]
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| - | [[Category: Palacios, A.]]
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| - | [[Category: ZN]]
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| - | [[Category: phd]]
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| - | [[Category: zn]]
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:56:35 2007''
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