2fwm

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[[Image:2fwm.gif|left|200px]]
 
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==Crystal Structure of E. coli EntA, a 2,3-dihydrodihydroxy benzoate dehydrogenase==
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The line below this paragraph, containing "STRUCTURE_2fwm", creates the "Structure Box" on the page.
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<StructureSection load='2fwm' size='340' side='right'caption='[[2fwm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FWM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fwm OCA], [https://pdbe.org/2fwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fwm RCSB], [https://www.ebi.ac.uk/pdbsum/2fwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fwm ProSAT]</span></td></tr>
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{{STRUCTURE_2fwm| PDB=2fwm | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure of E. coli EntA, a 2,3-dihydrodihydroxy benzoate dehydrogenase'''
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[https://www.uniprot.org/uniprot/ENTA_ECOLI ENTA_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The Escherichia coli enterobactin synthetic cluster is composed of six proteins, EntA-EntF, that form the enterobactin molecule from three serine molecules and three molecules of 2,3-dihydroxybenzoic acid (DHB). EntC, EntB and EntA catalyze the three-step synthesis of DHB from chorismate. EntA is a member of the short-chain oxidoreductase (SCOR) family of proteins and catalyzes the final step in DHB synthesis, the NAD+-dependent oxidation of 2,3-dihydro-2,3-dihydroxybenzoic acid to DHB. The structure of EntA has been determined by multi-wavelength anomalous dispersion methods. Here, the 2.0 A crystal structure of EntA in the unliganded form is presented. Analysis of the structure in light of recent structural and bioinformatic analysis of other members of the SCOR family provides insight into the residues involved in cofactor and substrate binding.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fw/2fwm_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2FWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWM OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fwm ConSurf].
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Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli., Sundlov JA, Garringer JA, Carney JM, Reger AS, Drake EJ, Duax WL, Gulick AM, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):734-40. Epub 2006, Jun 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16790929 16790929]
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<div style="clear:both"></div>
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[[Category: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase]]
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Duax, W L.]]
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[[Category: Duax WL]]
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[[Category: Gulick, A M.]]
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[[Category: Gulick AM]]
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[[Category: Chorismate metabolism]]
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[[Category: Enterobactin]]
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[[Category: Rossman fold]]
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[[Category: Short-chain oxidoreductase]]
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[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:23:31 2008''
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Current revision

Crystal Structure of E. coli EntA, a 2,3-dihydrodihydroxy benzoate dehydrogenase

PDB ID 2fwm

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