2nqa

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(New page: 200px<br /> <applet load="2nqa" size="450" color="white" frame="true" align="right" spinBox="true" caption="2nqa, resolution 2.200&Aring;" /> '''Catalytic Domain o...)
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[[Image:2nqa.gif|left|200px]]<br />
 
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<applet load="2nqa" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2nqa, resolution 2.200&Aring;" />
 
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'''Catalytic Domain of Human Calpain 8'''<br />
 
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==About this Structure==
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==Catalytic Domain of Human Calpain 8==
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2NQA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and ACE as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Calpain-1 Calpain-1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 3.4.22.52] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2NQA OCA].
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<StructureSection load='2nqa' size='340' side='right'caption='[[2nqa]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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[[Category: Calpain-1]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[2nqa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptomyces_roseus Streptomyces roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NQA FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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[[Category: Arrowsmith, C.H.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AR7:AMINO{[(4S)-4-AMINO-5,5-DIHYDROXYPENTYL]AMINO}METHANIMINIUM'>AR7</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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[[Category: Bochkarev, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nqa OCA], [https://pdbe.org/2nqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nqa RCSB], [https://www.ebi.ac.uk/pdbsum/2nqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nqa ProSAT]</span></td></tr>
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[[Category: Butler-Cole, C.]]
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</table>
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[[Category: Davis, T.L.]]
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== Function ==
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[[Category: Dhe-Paganon, S.]]
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[https://www.uniprot.org/uniprot/CAN2_HUMAN CAN2_HUMAN] Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.[https://www.uniprot.org/uniprot/CAN8_HUMAN CAN8_HUMAN] Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex (By similarity).
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[[Category: Edwards, A.M.]]
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== Evolutionary Conservation ==
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[[Category: Jr., P.J.Finerty.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Paramanathan, R.]]
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Check<jmol>
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[[Category: SGC, Structural.Genomics.Consortium.]]
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<jmolCheckbox>
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[[Category: Sundstrom, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/2nqa_consurf.spt"</scriptWhenChecked>
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[[Category: Weigelt, J.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: ACE]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: CA]]
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</jmolCheckbox>
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[[Category: calpain; calcium-dependent cytoplasmic cysteine proteinases; papain-like; ef-hand; structural genomics; structural genomics consortium; sgc]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nqa ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:01:50 2007''
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==See Also==
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*[[Calpain 3D structures|Calpain 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Streptomyces roseus]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev A]]
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[[Category: Butler-Cole C]]
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[[Category: Davis TL]]
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[[Category: Dhe-Paganon S]]
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[[Category: Edwards AM]]
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[[Category: Finerty Jr PJ]]
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[[Category: Paramanathan R]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt J]]

Current revision

Catalytic Domain of Human Calpain 8

PDB ID 2nqa

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