2g2y

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[[Image:2g2y.gif|left|200px]]
 
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==Structure of E.coli FabD complexed with malonate==
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The line below this paragraph, containing "STRUCTURE_2g2y", creates the "Structure Box" on the page.
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<StructureSection load='2g2y' size='340' side='right'caption='[[2g2y]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2g2y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G2Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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{{STRUCTURE_2g2y| PDB=2g2y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g2y OCA], [https://pdbe.org/2g2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g2y RCSB], [https://www.ebi.ac.uk/pdbsum/2g2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g2y ProSAT]</span></td></tr>
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</table>
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'''Structure of E.coli FabD complexed with malonate'''
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== Function ==
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[https://www.uniprot.org/uniprot/FABD_ECOLI FABD_ECOLI]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Malonyl-CoA-acyl carrier protein transacylase (FabD; EC 2.3.1.39) is a key enzyme in the fatty-acid biosynthesis pathway of bacteria, catalyzing the transfer of a malonyl moiety from malonyl-CoA to holo acyl carrier protein (ACP), generating malonyl-ACP and free CoASH. Malonyl-ACP, which is the product of this reaction, is the key building block for de novo fatty-acid biosynthesis. Various binary complex structures of the Escherichia coli enzyme are presented, including that of the natural substrate malonyl-CoA, indicating the functional role of the highly conserved amino acids Gln11, Ser92, Arg117 and His201 and the stabilizing function of the preformed oxyanion hole during the enzymatic reaction. Based on the presented structural data, a possible new catalytic enzyme mechanism is discussed. The data obtained could be used in aiding the process of rational inhibitor design.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/2g2y_consurf.spt"</scriptWhenChecked>
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2G2Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G2Y OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography., Oefner C, Schulz H, D'Arcy A, Dale GE, Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):613-8. Epub 2006, May 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16699188 16699188]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g2y ConSurf].
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[[Category: Escherichia coli]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Oefner, C.]]
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</StructureSection>
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[[Category: Complex]]
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[[Category: Escherichia coli K-12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:37:43 2008''
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[[Category: Large Structures]]
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[[Category: Oefner C]]

Current revision

Structure of E.coli FabD complexed with malonate

PDB ID 2g2y

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