This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2nzj
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2nzj" size="450" color="white" frame="true" align="right" spinBox="true" caption="2nzj, resolution 2.5Å" /> '''The crystal structur...) |
|||
| (14 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2nzj.gif|left|200px]]<br /> | ||
| - | <applet load="2nzj" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2nzj, resolution 2.5Å" /> | ||
| - | '''The crystal structure of REM1 in complex with GDP'''<br /> | ||
| - | == | + | ==The crystal structure of REM1 in complex with GDP== |
| - | + | <StructureSection load='2nzj' size='340' side='right'caption='[[2nzj]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2nzj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NZJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NZJ FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nzj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nzj OCA], [https://pdbe.org/2nzj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nzj RCSB], [https://www.ebi.ac.uk/pdbsum/2nzj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nzj ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/REM1_HUMAN REM1_HUMAN] Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling. | |
| - | [ | + | == Evolutionary Conservation == |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | + | Check<jmol> | |
| - | [ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nz/2nzj_consurf.spt"</scriptWhenChecked> | |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | [ | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nzj ConSurf]. | |
| - | [ | + | <div style="clear:both"></div> |
| - | + | ||
| - | [ | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | [[ | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | [ | + | |
| - | [[ | + | |
| - | [ | + | |
| - | + | ||
| - | + | ==See Also== | |
| + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Berridge G]] | ||
| + | [[Category: Bray J]] | ||
| + | [[Category: Burgess N]] | ||
| + | [[Category: Doyle D]] | ||
| + | [[Category: Edwards A]] | ||
| + | [[Category: Elkins JM]] | ||
| + | [[Category: Gileadi O]] | ||
| + | [[Category: Gorrec F]] | ||
| + | [[Category: Johansson C]] | ||
| + | [[Category: Marsden B]] | ||
| + | [[Category: Papagrigoriou E]] | ||
| + | [[Category: Salah E]] | ||
| + | [[Category: Soundararajan M]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Turnbull AP]] | ||
| + | [[Category: Ugochukwu E]] | ||
| + | [[Category: Umeano C]] | ||
| + | [[Category: Watts S]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Yang X]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
The crystal structure of REM1 in complex with GDP
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berridge G | Bray J | Burgess N | Doyle D | Edwards A | Elkins JM | Gileadi O | Gorrec F | Johansson C | Marsden B | Papagrigoriou E | Salah E | Soundararajan M | Sundstrom M | Turnbull AP | Ugochukwu E | Umeano C | Watts S | Weigelt J | Yang X | Von Delft F
