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2ge7

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[[Image:2ge7.gif|left|200px]]
 
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==Structure of the C-terminal dimerization domain of infectious bronchitis virus nucleocapsid protein==
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The line below this paragraph, containing "STRUCTURE_2ge7", creates the "Structure Box" on the page.
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<StructureSection load='2ge7' size='340' side='right'caption='[[2ge7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ge7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Infectious_bronchitis_virus Infectious bronchitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GE7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ge7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ge7 OCA], [https://pdbe.org/2ge7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ge7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ge7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ge7 ProSAT]</span></td></tr>
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{{STRUCTURE_2ge7| PDB=2ge7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NCAP_IBVG NCAP_IBVG] Major structural component of virions that associates with genomic RNA to form a long, flexible, helical nucleocapsid. Interaction with the M protein leads to the formation of virus particles. Binds to cellular membranes and phospholipids. Elicits cell-mediated immunity. May play roles in viral transcription and translation, and/or replication.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ge/2ge7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ge7 ConSurf].
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<div style="clear:both"></div>
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'''Structure of the C-terminal dimerization domain of infectious bronchitis virus nucleocapsid protein'''
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Coronaviruses cause a variety of respiratory and enteric diseases in animals and humans including severe acute respiratory syndrome. In these enveloped viruses, the filamentous nucleocapsid is formed by the association of nucleocapsid (N) protein with single-stranded viral RNA. The N protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. We describe the structure of the two proteolytically resistant domains of the N protein from infectious bronchitis virus (IBV), a prototype coronavirus. These domains are located at its N- and C-terminal ends (NTD and CTD, respectively). The NTD of the IBV Gray strain at 1.3-A resolution exhibits a U-shaped structure, with two arms rich in basic residues, providing a module for specific interaction with RNA. The CTD forms a tightly intertwined dimer with an intermolecular four-stranded central beta-sheet platform flanked by alpha helices, indicating that the basic building block for coronavirus nucleocapsid formation is a dimeric assembly of N protein. The variety of quaternary arrangements of the NTD and CTD revealed by the analysis of the different crystal forms delineates possible interfaces that could be used for the formation of a flexible filamentous ribonucleocapsid. The striking similarity between the dimeric structure of CTD and the nucleocapsid-forming domain of a distantly related arterivirus indicates a conserved mechanism of nucleocapsid formation for these two viral families.
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==About this Structure==
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2GE7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Infectious_bronchitis_virus Infectious bronchitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GE7 OCA].
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==Reference==
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X-ray structures of the N- and C-terminal domains of a coronavirus nucleocapsid protein: implications for nucleocapsid formation., Jayaram H, Fan H, Bowman BR, Ooi A, Jayaram J, Collisson EW, Lescar J, Prasad BV, J Virol. 2006 Jul;80(13):6612-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16775348 16775348]
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[[Category: Infectious bronchitis virus]]
[[Category: Infectious bronchitis virus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bowman, B R.]]
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[[Category: Bowman BR]]
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[[Category: Collisson, E W.]]
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[[Category: Collisson EW]]
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[[Category: Fan, H.]]
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[[Category: Fan H]]
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[[Category: Jayaram, H.]]
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[[Category: Jayaram H]]
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[[Category: Jayaram, J.]]
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[[Category: Jayaram J]]
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[[Category: Lescar, J.]]
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[[Category: Lescar J]]
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[[Category: Ooi, A.]]
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[[Category: Ooi A]]
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[[Category: Prasad, B V.]]
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[[Category: Prasad BV]]
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[[Category: Coronavirus]]
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[[Category: Dimerization domain]]
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[[Category: Ibv n protein]]
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[[Category: N protein]]
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[[Category: Nucleocapsid protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:00:13 2008''
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Current revision

Structure of the C-terminal dimerization domain of infectious bronchitis virus nucleocapsid protein

PDB ID 2ge7

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