2glw

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[[Image:2glw.gif|left|200px]]
 
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==The solution structure of PHS018 from pyrococcus horikoshii==
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The line below this paragraph, containing "STRUCTURE_2glw", creates the "Structure Box" on the page.
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<StructureSection load='2glw' size='340' side='right'caption='[[2glw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2glw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GLW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2glw OCA], [https://pdbe.org/2glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2glw RCSB], [https://www.ebi.ac.uk/pdbsum/2glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2glw ProSAT]</span></td></tr>
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{{STRUCTURE_2glw| PDB=2glw | SCENE= }}
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</table>
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== Function ==
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'''The solution structure of PHS018 from pyrococcus horikoshii'''
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[https://www.uniprot.org/uniprot/O73971_PYRHO O73971_PYRHO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The core of swapped-hairpin and double-psi beta barrels is formed by duplication of a conserved betaalphabeta element, suggesting a common evolutionary origin. The path connecting the two folds is unclear as the two barrels are not interconvertible by a simple topological modification, such as circular permutation. We have identified a protein family whose sequence properties are intermediate to the two folds. The structure of one of these proteins, Pyrococcus horikoshii PhS018, is also built by duplication of the conserved betaalphabeta element but shows yet a third topology, which we name the RIFT barrel. This topology is widespread in the structure database and spans three folds of the SCOP classification, including the middle domain of EF-Tu and the N domain of F1-ATPase. We propose that swapped-hairpin beta barrels arose from an ancestral RIFT barrel by strand invasion and double-psi beta barrels by a strand swap. We group the three barrel types into a metafold, the cradle-loop barrels.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gl/2glw_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2GLW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GLW OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2glw ConSurf].
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Common evolutionary origin of swapped-hairpin and double-psi beta barrels., Coles M, Hulko M, Djuranovic S, Truffault V, Koretke K, Martin J, Lupas AN, Structure. 2006 Oct;14(10):1489-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17027498 17027498]
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<div style="clear:both"></div>
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[[Category: Pyrococcus horikoshii]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Coles, M.]]
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[[Category: Large Structures]]
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[[Category: Hulko, M.]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: Lupas, A N.]]
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[[Category: Coles M]]
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[[Category: Martin, J.]]
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[[Category: Hulko M]]
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[[Category: Truffault, V.]]
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[[Category: Lupas AN]]
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[[Category: Bioinformatic]]
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[[Category: Martin J]]
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[[Category: Nmr]]
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[[Category: Truffault V]]
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[[Category: Rift barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:15:11 2008''
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Current revision

The solution structure of PHS018 from pyrococcus horikoshii

PDB ID 2glw

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