2gza

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[[Image:2gza.gif|left|200px]]
 
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==Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate==
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The line below this paragraph, containing "STRUCTURE_2gza", creates the "Structure Box" on the page.
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<StructureSection load='2gza' size='340' side='right'caption='[[2gza]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gza]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_suis_1330 Brucella suis 1330]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GZA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2gza| PDB=2gza | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gza OCA], [https://pdbe.org/2gza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gza RCSB], [https://www.ebi.ac.uk/pdbsum/2gza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gza ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate'''
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== Function ==
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[https://www.uniprot.org/uniprot/VIRBB_BRUSU VIRBB_BRUSU] The VirB system could be required for the establishment of the replication niche in the host.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/2gza_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gza ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
VirB11 ATPases are hexameric assemblies that power type IV secretion systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring structure formed by the N-terminal and C-terminal domains of each monomer. However, the monomer differs dramatically from that of Hp0525 by a large domain swap that leaves the hexameric assembly intact but profoundly alters the nucleotide-binding site and the interface between subunits.
VirB11 ATPases are hexameric assemblies that power type IV secretion systems in bacteria. The hexamer of Brucella suis VirB11 (BsB11), like that of the Helicobacter pylori VirB11 (Hp0525), consists of a double ring structure formed by the N-terminal and C-terminal domains of each monomer. However, the monomer differs dramatically from that of Hp0525 by a large domain swap that leaves the hexameric assembly intact but profoundly alters the nucleotide-binding site and the interface between subunits.
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==About this Structure==
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A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact.,Hare S, Bayliss R, Baron C, Waksman G J Mol Biol. 2006 Jun 30;360(1):56-66. Epub 2006 May 11. PMID:16730027<ref>PMID:16730027</ref>
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2GZA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brucella_suis Brucella suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GZA OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact., Hare S, Bayliss R, Baron C, Waksman G, J Mol Biol. 2006 Jun 30;360(1):56-66. Epub 2006 May 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16730027 16730027]
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</div>
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[[Category: Brucella suis]]
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<div class="pdbe-citations 2gza" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Baron, C.]]
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<references/>
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[[Category: Bayliss, R.]]
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__TOC__
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[[Category: Hare, S.]]
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</StructureSection>
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[[Category: Waksman, G]]
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[[Category: Brucella suis 1330]]
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[[Category: Atpase]]
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[[Category: Large Structures]]
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[[Category: Secretion]]
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[[Category: Baron C]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:40:51 2008''
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[[Category: Bayliss R]]
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[[Category: Hare S]]
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[[Category: Waksman G]]

Current revision

Crystal structure of the VirB11 ATPase from the Brucella Suis type IV secretion system in complex with sulphate

PDB ID 2gza

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