2h63

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[[Image:2h63.gif|left|200px]]
 
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==Crystal Structure of Human Biliverdin Reductase A==
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The line below this paragraph, containing "STRUCTURE_2h63", creates the "Structure Box" on the page.
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<StructureSection load='2h63' size='340' side='right'caption='[[2h63]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2h63]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H63 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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{{STRUCTURE_2h63| PDB=2h63 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h63 OCA], [https://pdbe.org/2h63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h63 RCSB], [https://www.ebi.ac.uk/pdbsum/2h63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h63 ProSAT]</span></td></tr>
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</table>
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'''Crystal Structure of Human Biliverdin Reductase A (CASP Target)'''
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== Disease ==
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[https://www.uniprot.org/uniprot/BIEA_HUMAN BIEA_HUMAN] Defects in BLVRA are the cause of hyperbiliverdinemia (HBLVD) [MIM:[https://omim.org/entry/614156 614156]. HBLVD is a condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis.
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== Function ==
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==About this Structure==
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[https://www.uniprot.org/uniprot/BIEA_HUMAN BIEA_HUMAN] Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor.
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2H63 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H63 OCA].
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== Evolutionary Conservation ==
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[[Category: Biliverdin reductase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/2h63_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h63 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins J]]
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[[Category: Elkins, J.]]
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[[Category: Guo K]]
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[[Category: Guo, K.]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K.]]
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[[Category: Lukacik P]]
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[[Category: Lukacik, P.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Pilka E]]
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[[Category: Pilka, E.]]
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[[Category: Smee C]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Smee, C.]]
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[[Category: Ugochukwu E]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Ugochukwu, E.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: Biliverdin reductase]]
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[[Category: Blvra]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:54:38 2008''
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Current revision

Crystal Structure of Human Biliverdin Reductase A

PDB ID 2h63

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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