2oyc

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(New page: 200px<br /> <applet load="2oyc" size="450" color="white" frame="true" align="right" spinBox="true" caption="2oyc, resolution 1.720&Aring;" /> '''Crystal structure ...)
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[[Image:2oyc.gif|left|200px]]<br />
 
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<applet load="2oyc" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2oyc, resolution 1.720&Aring;" />
 
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'''Crystal structure of human pyridoxal phosphate phosphatase'''<br />
 
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==Disease==
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==Crystal structure of human pyridoxal phosphate phosphatase==
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Known diseases associated with this structure: Pelizaeus-Merzbacher disease OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300401 300401]], Spastic paraplegia-2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300401 300401]]
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<StructureSection load='2oyc' size='340' side='right'caption='[[2oyc]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OYC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyc OCA], [https://pdbe.org/2oyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oyc RCSB], [https://www.ebi.ac.uk/pdbsum/2oyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oyc ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2oyc TOPSAN]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/2oyc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oyc ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
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==About this Structure==
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Structural genomics of protein phosphatases.,Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037<ref>PMID:18058037</ref>
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2OYC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NA and WO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pyridoxal_phosphatase Pyridoxal phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.74 3.1.3.74] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2OYC OCA].
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[[Category: Homo sapiens]]
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[[Category: Pyridoxal phosphatase]]
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[[Category: Single protein]]
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[[Category: Almo, S.C.]]
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[[Category: Burley, S.K.]]
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[[Category: Freeman, J.]]
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[[Category: Izuka, M.]]
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[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
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[[Category: Ramagopal, U.A.]]
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[[Category: Sauder, J.M.]]
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[[Category: Toro, R.]]
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[[Category: NA]]
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[[Category: WO4]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: phosphatase]]
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:18:11 2007''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2oyc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Almo SC]]
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[[Category: Burley SK]]
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[[Category: Freeman J]]
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[[Category: Izuka M]]
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[[Category: Ramagopal UA]]
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[[Category: Sauder JM]]
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[[Category: Toro R]]

Current revision

Crystal structure of human pyridoxal phosphate phosphatase

PDB ID 2oyc

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