2p0w

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(New page: 200px<br /> <applet load="2p0w" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p0w, resolution 1.90&Aring;" /> '''Human histone acety...)
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[[Image:2p0w.gif|left|200px]]<br />
 
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<applet load="2p0w" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2p0w, resolution 1.90&Aring;" />
 
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'''Human histone acetyltransferase 1 (HAT1)'''<br />
 
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==About this Structure==
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==Human histone acetyltransferase 1 (HAT1)==
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2P0W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ACT, CL, ACO and ACM as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2P0W OCA].
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<StructureSection load='2p0w' size='340' side='right'caption='[[2p0w]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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[[Category: Histone acetyltransferase]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[2p0w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P0W FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Arrowsmith, C.H.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACM:ACETAMIDE'>ACM</scene>, <scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Bochkarev, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p0w OCA], [https://pdbe.org/2p0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p0w RCSB], [https://www.ebi.ac.uk/pdbsum/2p0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p0w ProSAT]</span></td></tr>
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[[Category: Edwards, A.M.]]
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</table>
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[[Category: Loppnau, P.]]
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== Function ==
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[[Category: Min, J.]]
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[https://www.uniprot.org/uniprot/HAT1_HUMAN HAT1_HUMAN] Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.<ref>PMID:9427644</ref> <ref>PMID:11585814</ref> <ref>PMID:20953179</ref>
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[[Category: Plotnikov, A.N.]]
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== Evolutionary Conservation ==
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[[Category: SGC, Structural.Genomics.Consortium.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Sundstrom, M.]]
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Check<jmol>
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[[Category: Weigelt, J.]]
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<jmolCheckbox>
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[[Category: Wu, H.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p0/2p0w_consurf.spt"</scriptWhenChecked>
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[[Category: Zeng, H.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: ACM]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: ACO]]
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</jmolCheckbox>
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[[Category: ACT]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p0w ConSurf].
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[[Category: CL]]
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<div style="clear:both"></div>
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[[Category: hat1]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:19:14 2007''
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==See Also==
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*[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev A]]
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[[Category: Edwards AM]]
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[[Category: Loppnau P]]
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[[Category: Min J]]
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[[Category: Plotnikov AN]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt J]]
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[[Category: Wu H]]
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[[Category: Zeng H]]

Current revision

Human histone acetyltransferase 1 (HAT1)

PDB ID 2p0w

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