2hbn

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[[Image:2hbn.gif|left|200px]]
 
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==Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex==
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The line below this paragraph, containing "STRUCTURE_2hbn", creates the "Structure Box" on the page.
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<StructureSection load='2hbn' size='340' side='right'caption='[[2hbn]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hbn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HBN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TL:THALLIUM+(I)+ION'>TL</scene></td></tr>
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{{STRUCTURE_2hbn| PDB=2hbn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hbn OCA], [https://pdbe.org/2hbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hbn RCSB], [https://www.ebi.ac.uk/pdbsum/2hbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hbn ProSAT]</span></td></tr>
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</table>
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'''Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex'''
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The crystal structure of the Tl+ form of the G-quadruplex formed from the Oxytricha nova telomere sequence, d(G4T4G4), has been solved to 1.55 A. This G-quadruplex contains five Tl+ ions, three of which are interspersed between adjacent G-quartet planes and one in each of the two thymine loops. The structure displays a high degree of similarity to the K+ crystal structure [Haider et al. (2002), J. Mol. Biol., 320, 189-200], including the number and location of the monovalent cation binding sites. The highly isomorphic nature of the two structures, which contain such a large number of monovalent binding sites (relative to nucleic acid content), verifies the ability of Tl+ to mimic K+ in nucleic acids. Information from this report confirms and extends the assignment of 205Tl resonances from a previous report [Gill et al. (2005), J. Am. Chem. Soc., 127, 16 723-16 732] where 205Tl NMR was used to study monovalent cation binding to this G-quadruplex. The assignment of these resonances provides evidence for the occurrence of conformational dynamics in the thymine loop region that is in slow exchange on the 205Tl timescale.
The crystal structure of the Tl+ form of the G-quadruplex formed from the Oxytricha nova telomere sequence, d(G4T4G4), has been solved to 1.55 A. This G-quadruplex contains five Tl+ ions, three of which are interspersed between adjacent G-quartet planes and one in each of the two thymine loops. The structure displays a high degree of similarity to the K+ crystal structure [Haider et al. (2002), J. Mol. Biol., 320, 189-200], including the number and location of the monovalent cation binding sites. The highly isomorphic nature of the two structures, which contain such a large number of monovalent binding sites (relative to nucleic acid content), verifies the ability of Tl+ to mimic K+ in nucleic acids. Information from this report confirms and extends the assignment of 205Tl resonances from a previous report [Gill et al. (2005), J. Am. Chem. Soc., 127, 16 723-16 732] where 205Tl NMR was used to study monovalent cation binding to this G-quadruplex. The assignment of these resonances provides evidence for the occurrence of conformational dynamics in the thymine loop region that is in slow exchange on the 205Tl timescale.
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==About this Structure==
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Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex.,Gill ML, Strobel SA, Loria JP Nucleic Acids Res. 2006;34(16):4506-14. Epub 2006 Aug 31. PMID:16945956<ref>PMID:16945956</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HBN OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex., Gill ML, Strobel SA, Loria JP, Nucleic Acids Res. 2006;34(16):4506-14. Epub 2006 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16945956 16945956]
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</div>
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[[Category: Gill, M L.]]
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<div class="pdbe-citations 2hbn" style="background-color:#fffaf0;"></div>
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[[Category: Loria, J P.]]
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== References ==
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[[Category: Strobel, S A.]]
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<references/>
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[[Category: Deoxyribonucleic acid]]
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__TOC__
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[[Category: G-quadruplex]]
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</StructureSection>
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[[Category: Thallium]]
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[[Category: Large Structures]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:05:44 2008''
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[[Category: Gill ML]]
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[[Category: Loria JP]]
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[[Category: Strobel SA]]

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Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex

PDB ID 2hbn

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