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2p1f
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(Difference between revisions)
(New page: 200px<br /> <applet load="2p1f" size="450" color="white" frame="true" align="right" spinBox="true" caption="2p1f, resolution 1.76Å" /> '''Human UMP Synthase ...) |
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| - | [[ | + | ==Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase)== |
| - | < | + | <StructureSection load='2p1f' size='340' side='right' caption='[[2p1f]], [[Resolution|resolution]] 1.76Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ''' | + | <table><tr><td colspan='2'>[[2p1f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P1F FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2eaw|2eaw]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p1f OCA], [http://pdbe.org/2p1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2p1f RCSB], [http://www.ebi.ac.uk/pdbsum/2p1f PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p1/2p1f_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p1f ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Uridine 5'-monophosphate synthase|Uridine 5'-monophosphate synthase]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | + | [[Category: Human]] | |
| - | [[Category: Liu, Y | + | [[Category: Liu, Y]] |
| - | [[Category: Pai, E | + | [[Category: Pai, E F]] |
| - | [[Category: Tang, H | + | [[Category: Tang, H L]] |
| - | [[Category: | + | [[Category: C-terminal domain]] |
| - | + | [[Category: Hydrolase]] | |
| - | + | [[Category: Orotidine 5'-monophosphate decarboxylase]] | |
| - | + | [[Category: Ump synthase]] | |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Current revision
Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase)
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