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2hfo

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[[Image:2hfo.jpg|left|200px]]
 
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==Crystal Structures of the Synechocystis Photoreceptor Slr1694 Reveal Distinct Structural States Related to Signaling==
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The line below this paragraph, containing "STRUCTURE_2hfo", creates the "Structure Box" on the page.
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<StructureSection load='2hfo' size='340' side='right'caption='[[2hfo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hfo]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechocystis_sp._PCC_6803 Synechocystis sp. PCC 6803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HFO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_2hfo| PDB=2hfo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hfo OCA], [https://pdbe.org/2hfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hfo RCSB], [https://www.ebi.ac.uk/pdbsum/2hfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hfo ProSAT]</span></td></tr>
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</table>
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'''Crystal Structures of the Synechocystis Photoreceptor Slr1694 Reveal Distinct Structural States Related to Signaling'''
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== Function ==
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[https://www.uniprot.org/uniprot/P74295_SYNY3 P74295_SYNY3]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Crystal structures of the Synechocystis BLUF phototaxis photoreceptor Slr1694 have been determined in two crystal forms, a monoclinic form at 1.8 A resolution and an orthorhombic form at 2.1 A resolution. In both forms, the photoreceptor is comprised of two pentamer rings stacked face to face. Twenty total subunits in the two asymmetric units of these crystal forms display three distinct tertiary structures that differ in the length of the fifth beta-strand and in the orientation of Trp91, a conserved Trp residue near the FMN chromophore. Fluorescence spectroscopic analysis on Slr1694 in solution is consistent with motion of Trp91 from a hydrophobic environment in the dark state to a more hydrophilic environment in the light-excited state. Mutational analysis indicates that movement of Trp91 is dependent on the occupancy of the hydrophobic Trp binding pocket with a nearby Met. These different tertiary structures may be associated with absorption changes in the blue region of the spectrum.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/2hfo_consurf.spt"</scriptWhenChecked>
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2HFO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechocystis_sp. Synechocystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFO OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structures of the Synechocystis photoreceptor Slr1694 reveal distinct structural states related to signaling., Yuan H, Anderson S, Masuda S, Dragnea V, Moffat K, Bauer C, Biochemistry. 2006 Oct 24;45(42):12687-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17042486 17042486]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hfo ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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[[Category: Synechocystis sp.]]
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__TOC__
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[[Category: Anderson, S.]]
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</StructureSection>
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[[Category: Bauer, C E.]]
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[[Category: Large Structures]]
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[[Category: Dragnea, V.]]
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[[Category: Synechocystis sp. PCC 6803]]
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[[Category: Masuda, S.]]
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[[Category: Anderson S]]
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[[Category: Moffat, K.]]
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[[Category: Bauer CE]]
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[[Category: Yuan, H.]]
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[[Category: Dragnea V]]
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[[Category: Beta sheet ferredoxin-like fold]]
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[[Category: Masuda S]]
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[[Category: Flavin binding protein]]
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[[Category: Moffat K]]
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[[Category: Photoreceptor]]
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[[Category: Yuan H]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:14:08 2008''
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Current revision

Crystal Structures of the Synechocystis Photoreceptor Slr1694 Reveal Distinct Structural States Related to Signaling

PDB ID 2hfo

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