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2hy9

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[[Image:2hy9.gif|left|200px]]
 
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==Human telomere DNA quadruplex structure in K+ solution hybrid-1 form==
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The line below this paragraph, containing "STRUCTURE_2hy9", creates the "Structure Box" on the page.
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<StructureSection load='2hy9' size='340' side='right'caption='[[2hy9]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hy9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HY9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hy9 OCA], [https://pdbe.org/2hy9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hy9 RCSB], [https://www.ebi.ac.uk/pdbsum/2hy9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hy9 ProSAT]</span></td></tr>
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{{STRUCTURE_2hy9| PDB=2hy9 | SCENE= }}
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</table>
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__TOC__
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'''solution structure of the human telomeric quadruplex'''
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==Overview==
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[[Category: Dai J]]
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We report the NMR solution structure of the intramolecular G-quadruplex formed in human telomeric DNA in K(+). The hybrid-type telomeric G-quadruplex consists of three G-tetrads linked with mixed parallel-antiparallel G-strands, with the bottom two G-tetrads having the same G-arrangement (anti:anti:syn:anti) and the top G-tetrad having the reversed G-arrangement (syn:syn:anti:syn). The three TTA loop segments adopt different conformations, with the first TTA assuming a double-chain-reversal loop conformation, and the second and third TTA assuming lateral loop conformations. The NMR structure is very well defined, including the three TTA loops and the two flanking sequences at 5'- and 3'-ends. Our study indicates that the three loop regions interact with the core G-tetrads in a specific way that defines and stabilizes the unique human telomeric G-quadruplex structure in K(+). Significantly, a novel adenine triple platform is formed with three naturally occurring adenine residues, A21, A3 and A9, capping the top tetrad of the hybrid-type telomeric G-quadruplex. This adenine triple is likely to play an important role in the formation of a stable human telomeric G-quadruplex structure in K(+). The unique human telomeric G-quadruplex structure formed in K(+) suggests that it can be specifically targeted for anticancer drug design.
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[[Category: Hurley L]]
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[[Category: Jones RA]]
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==About this Structure==
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[[Category: Punchihewa C]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY9 OCA].
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[[Category: Yang D]]
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==Reference==
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Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation., Dai J, Punchihewa C, Ambrus A, Chen D, Jones RA, Yang D, Nucleic Acids Res. 2007;35(7):2440-50. Epub 2007 Mar 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17395643 17395643]
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[[Category: Dai, J.]]
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[[Category: Hurley, L.]]
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[[Category: Jones, R A.]]
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[[Category: Punchihewa, C.]]
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[[Category: Yang, D.]]
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[[Category: G-quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:51:43 2008''
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Current revision

Human telomere DNA quadruplex structure in K+ solution hybrid-1 form

PDB ID 2hy9

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