Structural highlights
Function
JZTX3_CHIGU Selectively inhibits activation of voltage-gated sodium channels (VGSC) (Nav1.5/SCN5A) in rat cardiac myocytes, followed by shifting activated voltage in a depolarizing direction. The binding site on VGSC is suggested to be site 4 located at the extracellular S3-S4 loop of the channel. Also binds to voltage-gated potassium channels (Kv2.1/KCNB1).[1]
References
- ↑ Yuan C, Yang S, Liao Z, Liang S. Effects and mechanism of Chinese tarantula toxins on the Kv2.1 potassium channels. Biochem Biophys Res Commun. 2007 Jan 19;352(3):799-804. Epub 2006 Nov 27. PMID:17150181 doi:http://dx.doi.org/10.1016/j.bbrc.2006.11.086
