2i6i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:52, 13 March 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2i6i.jpg|left|200px]]
 
-
<!--
+
==crystal structures of the archaeal sulfolobus PTP-fold phosphatase==
-
The line below this paragraph, containing "STRUCTURE_2i6i", creates the "Structure Box" on the page.
+
<StructureSection load='2i6i' size='340' side='right'caption='[[2i6i]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2i6i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I6I FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6i OCA], [https://pdbe.org/2i6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i6i RCSB], [https://www.ebi.ac.uk/pdbsum/2i6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i6i ProSAT]</span></td></tr>
-
{{STRUCTURE_2i6i| PDB=2i6i | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q97VZ7_SACS2 Q97VZ7_SACS2]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i6i_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i6i ConSurf].
 +
<div style="clear:both"></div>
-
'''crystal structures of the archaeal sulfolobus PTP-fold phosphatase'''
+
==See Also==
-
 
+
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
The P-loop-containing protein phos-phatases are important regulators in signal transduction. These enzymes have structural and functional similarity with a conserved sequence of Dx(25-41)HCxxGxxR(T/S) essential for catalysis. The singular protein tyrosine phosphatase (PTP) from archaeal Sulfolobus solfataricus is one of the smallest known PTPs with extreme thermostability. Here, we report the crystal structure of this phosphatase and its complexes with two tyrosyl phosphopeptides A-(p)Y-R and N-K-(p)Y-G-N. The structure suggests the minimal structural motif of the PTP family, having two variable sequences inserted between the beta2-beta3 and beta3-beta4 strands, respectively. The phosphate of both phosphopeptide substrates is bound to the P-loop through several hydrogen bonds. Comparison of several phosphatase-substrate complexes revealed that Gln135 on the Q-loop has different modes of recognition toward phosphopeptides. The substrate specificity of SsoPTP is primarily localized at the phosphotyrosine, suggesting that this phosphatase may be a prototypical PTP.
+
[[Category: Large Structures]]
-
 
+
[[Category: Saccharolobus solfataricus]]
-
==About this Structure==
+
[[Category: Chu HM]]
-
2I6I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6I OCA].
+
[[Category: Wang AHJ]]
-
 
+
-
==Reference==
+
-
Enzyme-substrate interactions revealed by the crystal structures of the archaeal Sulfolobus PTP-fold phosphatase and its phosphopeptide complexes., Chu HM, Wang AH, Proteins. 2007 Mar 1;66(4):996-1003. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17173287 17173287]
+
-
[[Category: Single protein]]
+
-
[[Category: Sulfolobus solfataricus]]
+
-
[[Category: Chu, H M.]]
+
-
[[Category: Wang, A H.J.]]
+
-
[[Category: Ptp domain]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:08:18 2008''
+

Current revision

crystal structures of the archaeal sulfolobus PTP-fold phosphatase

PDB ID 2i6i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i6i"
Personal tools