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2r4h
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="2r4h" size="450" color="white" frame="true" align="right" spinBox="true" caption="2r4h, resolution 2.05Å" /> '''Crystal structure o...) |
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| - | [[Image:2r4h.gif|left|200px]]<br /> | ||
| - | <applet load="2r4h" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2r4h, resolution 2.05Å" /> | ||
| - | '''Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase'''<br /> | ||
| - | == | + | ==Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase== |
| - | + | <StructureSection load='2r4h' size='340' side='right'caption='[[2r4h]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | + | <table><tr><td colspan='2'>[[2r4h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4h OCA], [https://pdbe.org/2r4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4h RCSB], [https://www.ebi.ac.uk/pdbsum/2r4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4h ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/MAGI1_HUMAN MAGI1_HUMAN] May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). |
| - | + | == Evolutionary Conservation == | |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4h_consurf.spt"</scriptWhenChecked> | |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | [[ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4h ConSurf]. |
| - | + | <div style="clear:both"></div> | |
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| - | + | ==See Also== | |
| + | *[[Guanylate kinase 3D structures|Guanylate kinase 3D structures]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Cooper C]] | ||
| + | [[Category: Doyle DA]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Elkins JM]] | ||
| + | [[Category: Hozjan V]] | ||
| + | [[Category: Kavanagh KL]] | ||
| + | [[Category: Oppermann U]] | ||
| + | [[Category: Pike ACW]] | ||
| + | [[Category: Pilka ES]] | ||
| + | [[Category: Sundstrom M]] | ||
| + | [[Category: Ugochukwu E]] | ||
| + | [[Category: Weigelt J]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Cooper C | Doyle DA | Edwards AM | Elkins JM | Hozjan V | Kavanagh KL | Oppermann U | Pike ACW | Pilka ES | Sundstrom M | Ugochukwu E | Weigelt J | Von Delft F
