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| - | [[Image:2ipy.gif|left|200px]] | + | #REDIRECT [[3snp]] This PDB entry is obsolete and replaced by 3snp |
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| - | {{STRUCTURE_2ipy| PDB=2ipy | SCENE= }}
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| - | '''crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA'''
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| - | ==Overview==
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| - | Iron regulatory protein 1 (IRP1) binds iron-responsive elements (IREs) in messenger RNAs (mRNAs), to repress translation or degradation, or binds an iron-sulfur cluster, to become a cytosolic aconitase enzyme. The 2.8 angstrom resolution crystal structure of the IRP1:ferritin H IRE complex shows an open protein conformation compared with that of cytosolic aconitase. The extended, L-shaped IRP1 molecule embraces the IRE stem-loop through interactions at two sites separated by approximately 30 angstroms, each involving about a dozen protein:RNA bonds. Extensive conformational changes related to binding the IRE or an iron-sulfur cluster explain the alternate functions of IRP1 as an mRNA regulator or enzyme.
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| - | ==About this Structure==
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| - | 2IPY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. The following page contains interesting information on the relation of 2IPY with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb89_1.html Aconitase and Iron Regulatory Protein 1]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IPY OCA].
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| - | ==Reference==
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| - | Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA., Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, Volz K, Science. 2006 Dec 22;314(5807):1903-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17185597 17185597]
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| - | [[Category: Aconitase and Iron Regulatory Protein 1]]
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| - | [[Category: Aconitate hydratase]]
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| - | [[Category: Oryctolagus cuniculus]]
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| - | [[Category: Single protein]]
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| - | [[Category: Dupuy, J.]]
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| - | [[Category: Fontecilla-Camps, J C.]]
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| - | [[Category: Selezneva, A I.]]
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| - | [[Category: Theil, E C.]]
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| - | [[Category: Volbeda, A.]]
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| - | [[Category: Volz, K.]]
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| - | [[Category: Walden, W E.]]
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| - | [[Category: Protein-rna complex]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:45:41 2008''
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