2ixq
From Proteopedia
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| - | [[Image:2ixq.gif|left|200px]] | ||
| - | < | + | ==The solution structure of the invasive tip complex from Afa-Dr fibrils== |
| - | + | <StructureSection load='2ixq' size='340' side='right'caption='[[2ixq]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2ixq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IXQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr> | |
| - | --> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ixq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ixq OCA], [https://pdbe.org/2ixq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ixq RCSB], [https://www.ebi.ac.uk/pdbsum/2ixq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ixq ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/Q7BG36_ECOLX Q7BG36_ECOLX] | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | == | + | Check<jmol> |
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ixq_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ixq ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition. | Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition. | ||
| - | + | The solution structure of the invasive tip complex from Afa/Dr fibrils.,Cota E, Jones C, Simpson P, Altroff H, Anderson KL, du Merle L, Guignot J, Servin A, Le Bouguenec C, Mardon H, Matthews S Mol Microbiol. 2006 Oct;62(2):356-66. Epub 2006 Sep 8. PMID:16965519<ref>PMID:16965519</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 2ixq" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Cota | + | </StructureSection> |
| - | [[Category: Guignot | + | [[Category: Escherichia coli]] |
| - | [[Category: Jones | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Altroff H]] |
| - | [[Category: | + | [[Category: Anderson KL]] |
| - | [[Category: | + | [[Category: Cota E]] |
| - | [[Category: Servin | + | [[Category: Guignot J]] |
| - | [[Category: Simpson | + | [[Category: Jones C]] |
| - | [[Category: | + | [[Category: Le Bouguenec C]] |
| - | + | [[Category: Mardon H]] | |
| - | + | [[Category: Matthews S]] | |
| - | + | [[Category: Servin A]] | |
| - | + | [[Category: Simpson P]] | |
| - | + | [[Category: Du Merle L]] | |
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Current revision
The solution structure of the invasive tip complex from Afa-Dr fibrils
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Categories: Escherichia coli | Large Structures | Altroff H | Anderson KL | Cota E | Guignot J | Jones C | Le Bouguenec C | Mardon H | Matthews S | Servin A | Simpson P | Du Merle L
