This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2j3p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:33, 13 December 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2j3p.jpg|left|200px]]
 
-
<!--
+
==crystal structure of rat FGF1 at 1.4 A==
-
The line below this paragraph, containing "STRUCTURE_2j3p", creates the "Structure Box" on the page.
+
<StructureSection load='2j3p' size='340' side='right'caption='[[2j3p]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2j3p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J3P FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2j3p| PDB=2j3p | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j3p OCA], [https://pdbe.org/2j3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j3p RCSB], [https://www.ebi.ac.uk/pdbsum/2j3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j3p ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FGF1_RAT FGF1_RAT] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j3/2j3p_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j3p ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.
-
'''CRYSTAL STRUCTURE OF RAT FGF1 AT 1.4 A'''
+
Structure of rat acidic fibroblast growth factor at 1.4 A resolution.,Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):65-8. Epub 2007 Jan 27. PMID:17277441<ref>PMID:17277441</ref>
-
 
+
-
 
+
-
==Overview==
+
-
Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
2J3P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J3P OCA].
+
</div>
 +
<div class="pdbe-citations 2j3p" style="background-color:#fffaf0;"></div>
-
==Reference==
+
==See Also==
-
Structure of rat acidic fibroblast growth factor at 1.4 A resolution., Kulahin N, Kiselyov V, Kochoyan A, Kristensen O, Kastrup JS, Berezin V, Bock E, Gajhede M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):65-8. Epub 2007 Jan 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17277441 17277441]
+
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Single protein]]
+
[[Category: Berezin V]]
-
[[Category: Berezin, V.]]
+
[[Category: Bock E]]
-
[[Category: Bock, E.]]
+
[[Category: Gajhede M]]
-
[[Category: Gajhede, M.]]
+
[[Category: Kristensen O]]
-
[[Category: Kristensen, O.]]
+
[[Category: Kulahin N]]
-
[[Category: Kulahin, N.]]
+
-
[[Category: Acidic fibroblast growth factor]]
+
-
[[Category: Angiogenesis]]
+
-
[[Category: Beta-trefoil]]
+
-
[[Category: Cytokine]]
+
-
[[Category: Developmental protein]]
+
-
[[Category: Differentiation]]
+
-
[[Category: Growth factor]]
+
-
[[Category: Heparin-binding]]
+
-
[[Category: Mitogen]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:17:17 2008''
+

Current revision

crystal structure of rat FGF1 at 1.4 A

PDB ID 2j3p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j3p"
Personal tools